Case Urology Translational Research Training Program (CUTRTP)

描述(由申请人提供)：包括生殖道(GU)状况在内的泌尿系统疾病可以是先天性或获得性的，恶性的或良性的，以及内科或外科的。2000年，仅排在前四位的泌尿外科疾病就有大约2500万人次去看医生和医院；然而，解决这些问题的研究组合滞后。大多数专家认为缺乏合格的科学家和泌尿科医生--科学家是最重要的促成因素。因此，凯斯西储大学(CWRU)医学中心(CWRU UI)的泌尿研究所成立了，其首要目标是迅速扩大翻译研究并培训新一代科学家和外科科学家。通过这项提案中要求的资金，我们建议建立CWRU泌尿学转化性研究培训计划(CUTRTP)，以扩大我们目前对两个方向的科学家(博士或医学博士候选人)和外科科学家(医学博士候选人)的培训支持，每年培训2至6名博士后或研究生(5年内共12名)。所有应聘者都必须有强烈的愿望追求学术医学的职业生涯，专注于翻译研究。理想的成功博士候选人将完成他们的培训，并可能完成0-1年的博士后工作。理想的成功医学博士候选人应在ACGME认可的项目中获得医学博士学位，并在泌尿外科、妇科或家庭医学方面完成住院医师资格，并有研究历史。CUTRTP基于3个培训支柱：1)在基础和临床导师的指导下，为受训者提供翻译，以对改善患者护理和结果产生更大影响；2)招募CWRU其他领域的顶尖研究人员作为未来研究人员的培训者；3)教学和专业培训，具有里程碑意义，由独立的评估委员会进行评估。利用有组织的课程，我们建议培训一批科学家和外科科学家，专注于3个主要领域的泌尿外科翻译研究：a)泌尿生殖系癌症，b)女性盆底疾病，c)肥胖和糖尿病的泌尿系统并发症。所有学员在两年的专心研究期间将获得相同的指导水平和承诺，并必须与其他合格的学员竞争第二年的职位。一个由来自15个部门的29名优秀培训人员组成的团队聚集在CUTRTP中，确保挑选、招聘、培训和交付一些最优秀的泌尿外科疾病科学家和外科科学家。

DESCRIPTION (provided by applicant): Urological diseases which include conditions of the genito-urinary tract (GU) can be congenital or acquired, malignant or benign, and medical or surgical. Roughly more than 25 million visits to physicians and hospitals took place in 2000 for just the top 4 urologic conditions; however, the research portfolio to address them lags. Most experts would consider the shortage of qualified scientists and urologists-scientists as the most important contributing factor. Thus, the Urology Institute of the Case Western Reserve University (CWRU) Medical Center (CWRU UI) was created with the overarching goal of rapid expansion of translational research and training of a new generation of scientists and surgeon-scientists. Through the funding requested in this proposal we propose to establish the CWRU Urology Translational Research Training Program (CUTRTP), to expand our current support for the training of 2 to 6 postdoctoral PhD or postgraduate MDs, per year (12 total over 5-years), in two tracks of scientists (for Ph.D. or M.D. candidates) and surgeon-scientists (for MD Candidates). All candidates must have a strong desire to pursue a career in academic medicine focusing on translational research. The ideal successful PhD candidates will have completed their training and potentially, 0-1 years of postdoctoral work. The ideal successful MD candidates will have received their MD and completed residency in urology, gynecology, or family medicine at an ACGME accredited program, and have a history of research. The CUTRTP is based on 3 training pillars: 1) a translational focus for trainees with basic and clinica mentors to yield greater impact on improved patient care and outcomes 2) recruitment of the top researchers from other fields at CWRU as trainers of future investigators, 3) didactic and professional training, with milestones, evaluated by an independent Evaluation Committee. Using a structured curriculum, we propose to train a group of scientists and surgeon-scientists to focus on translational urology research in 3 main areas: a) genitourinary cancers, b) female pelvic floor disorders, and c) urological complications of obesity and diabetes. All trainees will receive the same level and commitment of mentoring throughout their 2 years of devoted research and must compete for the 2nd year position with other qualified trainees. A group of 29 outstanding trainers from 15 departments with a cumulative NIH-funding total of approximately $30 million have come together in the CUTRTP to ensure selection, recruitment, training, and delivery of some of the best scientists and surgeon-scientists in urological diseases.