Acquisition of 700 MHz NMR Spectrometer

描述(由申请人提供)： 需要资金购买一台700 MHz核磁共振波谱仪，用于解决方案中的生物应用，以便安装在纽约结构生物学中心(NYSBC)，这是一个由纽约州九个研究机构组成的财团。所要求的700 MHz核磁共振光谱仪对于NYSBC的首要目的至关重要，以支持NIH资助的针对光谱仪主要用户和次要用户的研究的特定目标，并将取代NYSBC及其成员机构不再可用的高度使用的仪器。700 MHz核磁共振光谱仪填补了NYSBC的一个重要领域，允许进行多场自旋弛豫研究，并通过将特定实验与最合适的场强相匹配，促进更高场800和900 MHz仪器的最佳使用。在700 MHz仪器上进行的研究范围从生物分子结构/功能的基础研究，到阐明发病机制，到发现新的先导化合物，再到药物应用。

DESCRIPTION (provided by applicant): Funding is requested to purchase a 700 MHz NMR spectrometer for biological applications in solution for installation at the New York Structural Biology Center (NYSBC), a consortium of nine research institutions in New York State. The requested 700 MHz NMR spectrometer is essential to the over- riding purpose of the NYSBC to support the particular aims of the NIH-funded research of the major and minor users of the spectrometer and will replace a highly used instrument that is no longer available to NYSBC and its member institutions. A 700 MHz NMR spectrometer fills an essential niche at NYSBC, allowing multi-field spin relaxation studies and facilitating optimal usage of higher field 800 and 900 MHz instruments by matching particular experiments to the most appropriate field strengths. Research conducted on the 700 MHz instrument ranges from fundamental studies of structure/function of biomolecules, to elucidation of mechanisms of pathogenesis, to discovery of novel lead compounds to pharmaceutical applications.