Animal Facility Shared Resources

Wistar研究所癌症中心在该应用中提供了四种I型共享资源：动物设施、流式细胞术、成像和蛋白质表达。在过去的项目期间，癌症中心对第一类共享资源进行了大量投资，利用了720多万美元的资本资金和设备赠款，用于设备升级和设施改进。这些资源就像引擎一样，是癌症中心成员正在进行的研究的组成部分。第一类资源对癌症中心的科学目标产生了重大影响，贡献了三个科学项目报告的382篇独特的癌症相关出版物中的172篇（45%）。根据本申请中癌症中心管理部分的描述，通过任命专门的领导，对其共享资源进行了全面的重新调整，共享资源被分为I类或II类，反映了其服务的协作投入强度。第一类共享资源提供关键的、定义良好的服务，这些服务需要进行初步咨询，然后交付时间/格式定义的服务。通常需要通过协商为服务类型和数据分析提供协作输入，但此类服务通常通过退款实现或接近实现运营成本的全部回收。引入了明确的基准和客观的审查标准，以便对每个共享资源进行及时的监督、科学影响、服务质量和财务实力。对癌症中心的科学影响（一）和对每种资源的服务可持续性（二）的定期评估指导了共享资源的决策过程。总体而言，I型共享资源为研究提供了必不可少的基石，因为它们对发现的影响与所提供的可靠性、创新性和最先进的服务平台密不可分。

The Wistar Institute Cancer Center presents four Type I Shared Resources in this application: Animal Facility, Flow Cytometry, Imaging, and Protein Expression. During the past project period the Cancer Center made substantial investments in the Type I Shared Resources, utilizing over $7.2 million in capital funds and equipment grants for equipment upgrades and facility improvements. These Resources function as engines, integrated components ofthe research being conducted by Cancer Center members. The Type I Resources have demonstrated a significant impact to the scientific objectives ofthe Cancer Center, contributing to 172 of 382 (45%) of the unique cancer-related publications reported by the three scientific Programs. Following a comprehensive realignment of its Shared Resources by the appointment of dedicated leadership as described in the Cancer Center Administration section of this application, Shared Resources were grouped as Type I or Type II reflecting the intensity of collaborative input of their services. Type I Shared Resources provide critical and well-defined services that require an initial consultation followed by the delivery of time/format-defined services. Collaborative input for the type of service and data analysis is often required through consultation, yet such services generally achieve or are close in achieving full recovery of operating costs through chargebacks. Clear benchmarks and objective review criteria were introduced in order to enable timely oversight, scientific impact, quality of service, and financial strength for each Shared Resource. Regular evaluations of scientific impact for the Cancer Center (i) and sustainability of services (ii) for each resource guide the decision-making process for the Shared Resources. Overall Type I Shared Resources provide an essential cornerstone for research as their impact on discovery is inherent to the reliability, innovation, and state-of-the-art service platforms delivered.