Conduct of studies to evaluate the toxic and potential of vanadyl sulfate and sodium metavanadate in laboratory animals for the National Toxicology Program (NTP)

该项目的目标是评估五价钒化合物(偏钒酸钠)和四价钒化合物(钒硫酸盐)在饮用水中暴露后的毒性。对这两种化合物的为期两周的研究最近已经完成；NTP目前正在设计亚慢性研究。人类很可能同样暴露在饮用水中的这些化合物中。由于关于这些化合物的现有毒性数据很少，这些短期研究为设计更明确的生殖/发育和慢性毒性/致癌性研究提供了宝贵的数据。此外，为期两周的研究设计类似，可以比较五价钒和四价钒的毒性。 关键词：毒性，饮用水，钒，五价，四价，硫酸钒，偏钒酸钠。

The goal of this project is to evaluate the toxicity of pentavalent (sodium metavanadate) and tetravalent (vanadyl sulfate) vanadium compounds, following exposure in drinking water. Two-week studies of both compounds have been completed recently; subchronic studies are currently being designed by NTP. Humans are likely to be similarly exposed to these compounds in drinking water. As there are little available toxicity data on these compounds, these short-term studies provide valuable data to design more definitive reproductive/developmental and chronic toxicity/carcinogenicity studies. In addition, the 2-week studies were designed similarly to allow comparisons of the toxicity between pentavalent and tetravalent vanadium. Keywords: toxicity, drinking water, vanadium, pentavalent, tetravalent, vanadyl sulfate, sodium metavanadate.