AAOS/ORS Tackling Joint Disease by Understanding Crosstalk between Cartilage and Bone Research Symposium

 描述(申请人提供)：健康的关节无缝集成了多种组织的机械和生物功能，包括软骨、骨、滑膜、神经、血管和其他，以支持平稳、无痛的运动。令人惊讶的是，人们对支持这种整合的机制或在关节疾病中破坏这种整合的机制知之甚少。了解这些机制对于维持关节健康和治疗关节疾病至关重要，关节疾病是美国导致残疾的主要原因。关节疾病，如骨关节炎、骨坏死、幼年关节炎和创伤后关节炎使个人丧失能力。 影响着4600多万美国人的一生，其中包括超过一半的65岁以上人口。虽然对单个关节组织的研究进展已经阐明了关节疾病的机制，但还需要更多的研究来阐明这些组织相互作用的机制，以及导致这种串扰的局部和系统因素。因此，美国整形外科医生学会(AAOS)选择通过了解软骨和骨骼之间的串扰来治疗关节疾病作为2016年AAOS研究研讨会的主题。关节疾病的特殊负担促使了一次集中的、跨学科的研讨会，旨在推动更好的临床解决方案的开发。本次研讨会采用了一种创新的方法，以克服学科或科学专业知识的界限，这些界限限制了在理解关节内单个组织的整合方面的进展。研讨会的主要目标是邀请临床医生、工程师和生物学家分享每个学科关于骨、软骨、全身因素和其他组织之间的串扰在整个生命周期内对关节健康和疾病的影响的新概念。会议的结构支持这一目标，采用单一平台的形式，使整个小组能够一起审议和讨论选定的七个主题，以突出各个领域在联合串扰的背景下取得的进展。在这个为期2.5天的会议上，所有会议都邀请了科学领袖和开拓性的初级调查人员的演讲，他们正在应用新的想法和方法来了解联合功能。每次会议包括30分钟的结构化讨论，以确定该领域的前沿，确定知识差距，并建立新的研究优先事项。15个新调查者奖支持聘请不同的早期调查人员作为口头或海报主持人。除了发布研讨会的会议记录外，成果还包括在肌肉骨骼研究学会的年度会议上举办的研讨会、一个网络研讨会，以及将最新的研究优先事项纳入AAOS统一整形外科研究议程，该议程向资助机构、国会和公众传达肌肉骨骼研究的需求。鉴于对改进临床解决方案的迫切需求，以及骨和软骨研究的最新进展，本次研讨会将促进对话，以加快对关节组织间串扰的研究，以了解并最终治疗退行性关节疾病。

 DESCRIPTION (provided by applicant): The healthy joint seamlessly integrates the mechanical and biological functions of multiple tissues, including cartilage, bone, synovium, nerve, vasculature, and others, to support smooth, pain-free movement. Surprisingly little is known about the mechanisms that support this integration, or the mechanisms that disrupt it in joint disease. Understanding these mechanisms is central to maintaining joint health and treating joint disease, the leading cause of disability in the United States. Joint diseases such a osteoarthritis, osteonecrosis, juvenile arthritis, and post-traumatic arthritis disable individuals across the lifespan affecting over 46 million Americans, including more than half of the population over 65. While advances in the study of individual joint tissues have shed light on the mechanisms of joint disease, more research is needed to elucidate the mechanisms by which these tissues interact, and the local and systemic factors responsible for this crosstalk. Therefore, the American Academy of Orthopaedic Surgeons (AAOS) selected Tackling Joint Disease by Understanding Crosstalk between Cartilage and Bone as the topic for the 2016 AAOS Research Symposium. The exceptional burden of joint disease motivates a focused, interdisciplinary symposium designed to advance the development of better clinical solutions. This symposium takes an innovative approach to overcome the boundaries in disciplinary or scientific expertise that limit progress in understanding the integration of individual tissues in he joint. The primary objective of the symposium is to engage clinicians, engineers, and biologists to share emerging concepts from each discipline on crosstalk among bone, cartilage, systemic factors, and other tissues in joint health and disease across the lifespan. The structure of the meeting supports this goal, with a single-platform format that allows the entire group to consider together and discuss seven topics that were selected to highlight advances from individual fields within the context of joint crosstalk. All sessions at this 2.5-day meeting feature invited presentations by scientific leaders and pioneering junior investigators who are applying new ideas and approaches to understand joint function. Each session includes a 30 minute structured discussion to identify the leading edge of the field, determine gaps in knowledge, and establish new research priorities. Fifteen New Investigator Awards support the engagement of diverse early stage investigators as oral or poster presenters. In addition to publishing the proceedings of the symposium, outcomes include workshops at annual meetings of musculoskeletal research societies, a webinar, and inclusion of updated research priorities in the AAOS Unified Orthopaedic Research Agenda, which communicates musculoskeletal research needs to funding agencies, Congress, and the public. Given the urgent demand for improved clinical solutions, and the recent advances in bone and cartilage research, this symposium will stimulate the dialogue to accelerate research on crosstalk among tissues in the joint, to understand and ultimately treat degenerative joint disease.