Data Management, Biostatistics and Bioinformatics Core

数据管理、生物统计学和生物信息学戈尔(核心D)是宾夕法尼亚大学医学院(宾夕法尼亚大学)莫里斯·K·尤德尔帕金森氏症卓越研究中心(尤德尔中心)的组成部分。在这次由国家神经疾病和中风研究所(NINDS)继续为宾夕法尼亚大学尤德尔中心提供资金的竞争性续签申请中，核心D的目标是支持宾夕法尼亚大学尤德尔中心研究人员的数据管理、统计、生物信息学、数据库和相关计算需求。核心D提供的服务包括：(A)支持数据表格/问卷设计和开发、数据库开发和管理、数据录入、数据库审计跟踪、数据库安全、数据库备份和严格的数据质量控制程序；(B)为宾夕法尼亚大学Udall中心的所有活动提供计算和编程支持，包括实施和整合数据管理和研究所需的硬件和软件升级，对中心中心的计算系统进行例行和存档的异地备份；(C)为从开始到发表的所有研究方面提供生物统计学支持，包括制定研究设计、进行样本量和功率计算、随机化方案以及对中心数据进行分析，(D)为大型复杂数据集提供生物信息学支持；(E)维护和管理宾夕法尼亚大学Udall网站；(F)促进有效的工作关系，包括宾夕法尼亚大学Udall中心和国家卫生研究院指定的PD数据组织中心之间的数据共享。因此，核心D对宾夕法尼亚大学尤德尔中心的研究进展和进行研究至关重要，它将促进宾夕法尼亚大学尤德尔中心和其他尤德尔中心之间的协作互动。

The Data Management, Biostatistics and Bioinformatics Gore (Core D) is an integral part of the University of Pennsylvania School of Medicine (Penn) Morris K. Udall Parkinson's Disease Research Center of Excellence (Udall Center). The goal of Core D in this competing renewal application for continued funding of the Penn Udall Center by the National Institute of Neurological Disorders and Stroke (NINDS) is to support the data management, statistical, bioinformatics, database, and related computational needs of Penn Udall Center investigators. The services provided by Core D include: (a) support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) computing and programming support for all Penn Udall Center activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the Center, (c) biostatistical support for all study aspects from inception to publication, including development of study design, performing sample size and power calculations, randomization schemes, and performing analyses of the Center data, (d) bioinformatics support for large complex data set, (e) maintaining and curating the Penn Udall website, (f) promoting an effective working relationship including data sharing between the Penn Udall Center and the PD data organizing center designated by NIH. Thus, Core D plays an important and significant role that is critical to the progress of research and the conduct of studies in the Penn Udall Center, and it will foster collaborative interactions between the Penn Udall Center and other Udall Centers.