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Knowledge, Identification and Exploitation of dopaminergic axon guidance cues will improve cell replacement therapy for ParkinsonÍs disease.

Knowledge, Identification and Exploitation of dopaminergic axon guidance cues will improve cell replacement therapy for ParkinsonÍs disease.
多巴胺能轴突引导线索的知识、识别和利用将改善帕金森病的细胞替代疗法。
批准号:
nhmrc : 1022637
负责人:
A/Pr Clare Parish
金额:
$32.13万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31

项目摘要

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中文摘要
翻译
细胞移植治疗帕金森S病存在许多障碍,即移植物存活率低、适当回路的恢复以及新细胞足够的神经纤维生长。利用在胎儿发育过程中如何建立神经回路的知识,我们将尝试总结移植后的这些事件。此外,我们将在调节这些神经纤维的连通性和生长方面找到新的和新的线索。
英文摘要
Many obstacles exist for cell transplantation in ParkinsonÍs Disease; namely poor graft survival, restoration of appropriate circuitry and adequate nerve fiber growth from new cells. Using knowledge of how neural circuits are established during fetal development, we will attempt to recapitulate these events following transplantation. Further, we will identify new and novel cues in regulating the connectivity and growth of these nerve fibers.
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国内基金
海外基金
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    --
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