Training in Cardiovascular Translational Research

描述（由申请人提供）：本申请要求资助一个名为“心血管转化研究培训”的博士前（4个名额）和博士后（4个名额）培训补助金。这项培训补助金申请是专门为培养未来的CV科学家而设计的，他们将拥有将实验室的基本发现带入临床实践的专业知识，以开发新的治疗方法。IS培训计划的关键创新是一个为期三个学期的纵向课程，涵盖成功发现、验证和开发治疗方法所需的主要学科，包括：1）CV疾病的基本机制/靶点识别; 2）靶点给药/高通量筛选; 3）使用人类疾病的相关动物模型进行靶点验证/概念验证; 4）药物化学介绍-化合物/生物制剂的优化; 5）知识产权保护的基本概念; 6）医学药理学基础; 6）毒理学基础; 7）从临床前到IND申报的药物开发原则; 8）临床测试基础教师导师将指导四个主要领域的研究培训：1）CV信号分子的结构生物学，包括解决离子通道和G蛋白偶联受体的结构; 3）CV疾病的动物模型，包括心力衰竭、心律失常、动脉粥样硬化和糖尿病的小鼠模型;和4）临床转化CV科学，包括人类干细胞的综合利用，心血管疾病的遗传学，生物材料支架和生物反应器、临床电生理学和心力衰竭。非常重视培养具有广泛基础，跨学科知识和独特技能的科学家， 对心血管生物学和生理学有很强的基本理解。培训补助金的支助期限通常为两年，但个人参加培训方案的期限最长可达五年。培训补助金支助的受训人员将被要求并被建议申请独立供资，以便在两年后继续接受培训。博士前候选人是从优秀的申请人非常大的游泳池选择4个研究生课程在哥伦比亚大学医学中心-细胞生理学和生物物理学，综合计划，营养和代谢生物学，药理学和分子信号。博士后候选人也是从一个庞大的申请人库中挑选出来的，这个申请人库由直接申请项目教师和培训项目以及科学期刊上广告的受访者组成。为增加妇女和少数民族的招聘作出了特别努力。培训计划和核心部门有完善的心血管研讨会系列和期刊俱乐部，联合实验室会议和务虚会，旨在促进合作和跨学科研究。此外，培训计划本身还赞助了年度务虚会、研讨会和工作进展会议，以评估受训者的进展。培训计划有一个有效的评估和反馈系统，以确保我们的博士前学生和博士后研究员的适当培训。在整个计划和之后，学员被建议研究和职业发展，单独和通过辅导计划由副主任领导的培训生发展。该计划旨在利用哥伦比亚大学的许多现有优势，包括欧文临床和转化研究中心（CTSA），公共卫生，基因组中心，生物信息学，组织和生物医学工程和众多基础科学部门和强大的临床计划的梅尔曼学院。

DESCRIPTION (provided by applicant): This application requests funding for a pre-doctoral (4 slots) and post-doctoral (4 slots) training grant entitled, 'Training in Cardiovascular Translationl Research'. This training grant application is uniquely designed to train future CV scientists who will have expertise in bringing basic discoveries from the laboratory into clinical practice throug development of novel therapeutics. The KEY INNOVATION in the is training program is a longitudinal course over three semesters that covers the major disciplines required for successful therapeutics discovery, validation and development including: 1) basic mechanisms in CV diseases/target identification; 2) drugging the target/high throughput screening; 3) target validation/proof of concept using relevant animal models of human disease; 4) introduction to medicinal chemistry - optimization of compounds/biologicals; 5) basic concepts of intellectual property protection; 6) fundamentals of medical pharmacology; 6) basics in toxicology; 7) principals of drug development from pre-clinical to IND filing; 8) fundamentals of clinical testing Faculty mentors will direct research training in four primary areas: 1) Structural Biology of CV Signaling Molecules, including solving structures of ion channels and G-protein coupled receptors; 2) Biophysics of CV Cell Signaling, including ion channels, cardiac and smooth muscle signaling; 3) Animal Models of CV Diseases, including mice models of heart failure, cardiac arrhythmias, atherosclerosis, and diabetes; and 4) Clinical-Translational CV Sciences, including integrated use of human stem cells, genetics of cardiovascular diseases, biomaterial scaffolds and bioreactors, clinical electrophysiology, and heart failure. Strong emphasis is given to training scientists with broadly- based, interdisciplinary knowledge and unique skill sets, with a strong fundamental understanding of cardiovascular biology and physiology. The usual duration for support on the training grant is two years, although individuals may be enrolled in the training program for up to five years. Training-grant-supported trainees will be expected and counseled to apply for independent funding to continue their training after two years of grant support. Pre-doctoral candidates are selected from a very large pool of outstanding applicants to 4 graduate programs at Columbia University Medical Center- Cellular Physiology and Biophysics, Integrated Program, Nutritional and Metabolic Biology, Pharmacology and Molecular Signaling. Post-doctoral candidates are likewise selected from a large applicant pool made up of direct applications to program faculty and the training program, as well as respondents to advertisements in scientific journals. Special efforts are undertaken to enhance the recruitment of woman and minorities. The training program and the core departments have well-established cardiovascular seminar series and journal clubs, joint laboratory meetings and retreats that are designed to foster collaborations and interdisciplinary research. In addition, th training program itself sponsors an annual retreat, seminars and work-in-progress sessions to assess trainee progress. The training program has an efficient evaluation and feedback system to ensure appropriate training of our pre-doctoral students and post-doctoral fellows. Throughout the program and afterwards, trainees are advised on research and career development, individually and through a mentoring program headed by an Associate Director for Trainee Development. The program is designed to take advantage of the many existing strengths of Columbia University, including the Irving Center for Clinical and Translational Research (CTSA), Mailman School of Public Health, Genome Center, Bioinformatics, Tissue and Biomedical Engineering and numerous basic science departments and strong clinical programs.