Morehouse School of Medicine SNRP

描述(由申请人提供)：莫尔豪斯医学院(MSM)是一所年轻而充满活力的机构，通过培训医疗和科学专业人员，并通过重点发展基础和转化性研究环境，致力于探索该机构服务的人群中高疾病负担的障碍的机制，肩负着为弱势群体服务的强烈使命。为了与RFA的意图保持一致，并与其内部战略计划保持一致，MSM神经科学研究所建议扩大和加强其专注于NINDS任务相关研究的研究计划，并提高来自不同背景的学生对高级神经科学研究职业的学术准备。在这项申请中，我们提出了三个探索性项目，重点放在：(1)识别新的基因靶点来帮助治疗睡眠障碍(项目1，Pi的Paul和DeBruyne)。在这个项目中，Pi‘s将结合一个基因易驯化的动物模型的成熟的比较表型范例和强大的遗传图谱工具来识别新的睡眠调节基因；(Ii)了解酸感离子通道1a(ASICIa)介导的神经元信号通路的作用(项目2，Pi Xong)。在这项提案中，PI将定义ASICIa在生理和病理生理条件下介导的信号级联；以及(Iii)联合治疗对蛛网膜下腔出血后延迟性神经元恶化的有效性(项目3，Pi Namura)。该项目将测试甜菜碱(三甲基甘氨酸)和非诺贝特联合使用可能是治疗这种神经系统疾病的潜在策略的假设。应用程序的另外两个目标是：(I) 通过提供提高神经科学研究所教员竞争力的工具，培养和培养一支来自代表性不足群体的有竞争力的神经科学家队伍；以及(11)为研究生和博士后研究员提供培训机会，并扩大接触竞争性神经科学研究的本科生队伍。为了实现上述目标，我们将提供有效的管理和科学资源核心，以促进本应用程序的目标。

DESCRIPTION (provided by applicant): Morehouse School of Medicine (MSM) is a young and dynamic institution with a strong mission of service to the underserved through the training of medical and scientific professionals and through the focused development of a basic and translational research environment dedicated to exploring mechanisms of disorders with high disease burden in populations served by the institution. In keeping with the intent of the RFA and consistent with its internal strategic plan, the MSM Neuroscience Institute proposes to augment and strengthen its research programs focused on NINDS mission related research and to increase the academic preparedness of students from diverse backgrounds for advanced Neuroscience research careers. In this application, we proposed three exploratory projects that focus on: (1) Identifying new genetic targets to help treat sleep disorders (Project 1, Pi's Paul and DeBruyne). In this project, the Pi's will combine a well-established paradigm of comparative phenotyping of a genetically tractable animal model with powerful genetic mapping tools to identify novel sleep-regulatory gene; (ii) Understanding the role of Acid Sensing Ion Chanel 1a (ASICIa) -mediated signaling pathways in neurons (Project 2, PI Xiong). In this proposal, the PI will define ASICIa-mediated signaling cascades in physiological- and pathophysiological conditions; and (iii) The effectiveness of a combination therapy against delayed neuronal deterioration after subarachnoid hemorrhage (Project 3, PI Namura). This project will test the hypothesis that the combination of betaine (trimethylglycine) and fenofibrate may be a potential strategy for treating this neurological disease. Two other objectives of the application are (i) to train and develop a competitive cadre of neuroscientists from underrepresented groups by providing tools to enhance the competiveness of Neuroscience Institute faculty; and (11) to provide training opportunities for graduate students and postdoctoral fellows and to expand the pool of undergraduates exposed to competitive Neuroscience research. To accomplish the above goals, we will provide effective administrative and scientific resource cores to facilitate the goals of this application.