Phase resolved ARF optical coherence elastography for intravascular imaging

描述（由申请人提供）：拟议资助的广泛、长期目标是开发一种集成的多模态血管内成像系统，该系统结合了血管内光学相干断层扫描（OCT）、超声（US）和相位分辨声辐射力光学相干弹性成像（ARF-OCE）。多模式血管内成像系统的独特之处在于，它结合了OCT的高空间分辨率、US的宽成像深度和ARF-OCE的生物力学对比度的优点。可视化斑块以帮助了解疾病的进展并帮助诊断和治疗是非常可取的。体外和体内研究都表明，脂肪组织比纤维斑块具有更高的应变，并且易损斑块位于被低应变区域包围的高应变区域中。最近的研究指出，斑块的脆弱性和破裂的风险与纤维帽上的应力、帽厚度、动脉重塑和斑块的组成有关。因此，重要的是测量动脉组织的生物力学性质以监测动脉粥样硬化，从而减少动脉的破裂倾向并与临床症状和炎症标志物相关联。组合的多模式血管成像系统将允许具有高空间分辨率、宽成像深度和高生物力学灵敏度的脉管系统的横截面可视化，这是单独使用这些技术中的任何一种都不可能实现的。集成的OCT/US/ARF-OCE将为医生提供成像、诊断和管理易损斑块的强大工具。此外，在单个系统中的这种多模式成像策略允许使用单个一次性导丝和导管，从而降低医院和患者的成本，并通过早期检测改善预后。具体目标是：（1）设计和开发集成的血管内OCT/US/ARF-OCE成像探头，（2）设计和开发集成的血管内OCT/US/ARF-OCE系统，（3）开发用于图像重建和生物力学性质测定的算法，（4）使用集成的OCT/US/ARF-OCE系统对兔和猪动物模型的心血管斑块进行成像，以及（5）展示集成多模态成像系统在试验性体内人类受试者研究中的临床应用。预计这项研究将对心血管疾病的早期检测、预防和治疗产生重大影响。PHS 398

DESCRIPTION (provided by applicant): The broad, long term objective of the proposed grant is to develop an integrated multimodal intravascular imaging system that combines intravascular optical coherence tomography (OCT), ultrasound (US), and phase-resolved acoustic radiation force optical coherence elastography (ARF-OCE). The multimodal intravascular imaging system is unique in that it combines the advantages of the high spatial resolution of OCT, the broad imaging depth of US, and the biomechanical contrast of ARF-OCE. Visualizing plaques to help understand the progression of disease and to aid in diagnosis and treatment is highly desirable. Both in vitro and in vivo studies have shown that fatty tissue has a higher strain than fibrous plaques and that vulnerable plaques are in high strain areas surrounded by low strain areas. More recent studies have pointed to the vulnerability and the risk of rupturing of plaques being related to the stress on the fibrous cap, the cap thickness, arterial remodeling, and the composition of the plaques. Therefore, it is important to measure the biomechanical properties of the artery tissue to monitor the atherosclerosis to reduce the rupture proneness of an artery and to correlate with clinical symptoms and inflammation markers. The combined multimodal vascular imaging system will permit cross-sectional visualization of vasculature with high spatial resolution, broad imaging depth, and high biomechanical sensitivity, which is not possible by any of these technologies alone. The integrated OCT/US/ARF-OCE will provide the physician with a powerful tool for imaging, diagnosing, and managing vulnerable plaques. Furthermore, this multi-modal imaging strategy in a single system permits the use of a single disposable guide wire and catheter, thereby reducing costs to hospitals and patients, and improving prognosis by early detection. The specific aims are: (1) Design and develop an integrated intravascular OCT/US/ARF-OCE imaging probe, (2) Design and develop an integrated intravascular OCT/US/ARF-OCE system, (3) Develop algorithms for image reconstruction and biomechanical property determination, (4) Image cardiovascular plaques in rabbits and porcine animal models using an integrated OCT/US/ARF-OCE system, and (5) Demonstrate clinical applications of the integrated multimodal imaging system in pilot in vivo human subject studies. The proposed research is expected to have significant impact in the earlier detection, prevention, and treatment of cardiovascular diseases. PHS 398