ABCD-USA Consortium: Coordinating Center

 描述(由申请者提供)：ABCD-USA联合会提议进行一项研究，旨在允许我们的研究人员和科学界回答有关物质使用(SU)对青少年行为和大脑发育影响的重要问题。我们组建了一支研究团队，在青少年、儿童和青少年发展、发展精神病理学、纵向多部位成像、发育神经成像和认知神经科学、遗传学和成像遗传学、生物分析、流行病学、调查研究、生物信息学和移动评估技术方面拥有无与伦比的研究经验和专门知识。我们建议在全国范围内对10,000名9-10岁的儿童进行研究，该研究在11个中心的21个地点进行(29%的美国人口生活在我们地理分布的地点50英里以内)，这项研究独一无二地可以提供一个具有全国代表性的样本和一个大的双胞胎样本，这些样本结合在一起可以帮助区分与SU和大脑发育相关的环境、社会文化和遗传因素。我们通过由专业调查公司设计的招聘战略(监控未来的经验)确保凝聚力和标准化；标准化的环境、神经认知和精神健康评估，使用协调的人类连接项目程序的扫描仪磁共振评估，以及具有实时质量控制的计算机化数据收集。为发展量身定制的评估将具有稳定的敏感度和构建儿童和青春期的有效性，最大限度地减少参与者的负担，捕捉SU、心理健康、神经认知、发育和环境的细微变化，并采用新颖的生物测试和从移动设备收集被动数据。留任计划建立在我们调查人员的经验基础上，以确保成功。本申请描述了ABCD-美国协调中心(CC)，该中心将：为联合体提供全面的行政和后勤支持以及科学整合；为核心协议、参与者招募和保留以及数据质量控制建立和实施程序；提供人员的初始和持续标准化培训；实时监测队列属性、招募和保留做法、数据质量和整个联合体的一致性，并监测实现基准和时间表的进展。CC将确保遵守研究的道德标准和文化敏感性，并制定和实施争端解决、内部和外部数据共享和发布的政策。CC组织并为财团、指导委员会、科学咨询委员会和工作组的会议和电话会议以及教育、科学、外联和传播活动提供后勤支持。通过设计，CC过程在解决问题和纳入新出现的科学机会方面是灵活的。我们通过网络向公众提供透明的研究更新，以及管理良好和注释充分的数据存储库，以便及时共享。重要的是，我们为药物滥用领域的发展中的科学家提供培训和指导。

 DESCRIPTION (provided by applicant): The ABCD-USA Consortium proposes a study designed to permit our investigators and the scientific community to answer important questions about the effects of substance use (SU) on behavioral and brain development of adolescents. We have assembled a team of investigators with unparalleled research experience with youth, and specific expertise in adolescent SU, child and adolescent development, developmental psychopathology, longitudinal multi-site imaging, developmental neuroimaging and cognitive neuroscience, genetics and imaging genetics, bioassays, epidemiology, survey research, bioinformatics, and mobile assessment technologies. We propose a nationwide study of 10,000 9-10 year olds conducted at 21 sites organized into 11 hubs (29% of the US population lives within 50 miles of our geographically spread sites), that, uniquely, can provide a nationally representative sample and a large twin sample that together can help distinguish environmental, sociocultural, and genetic factors relevant to SU and brain development. We ensure cohesion and standardization with a recruitment strategy designed by a professional survey company (experience with Monitoring the Future); standardized environmental, neurocognitive and mental health assessments, MRI assessments with scanners using harmonized Human Connectome Project procedures, and computerized data collection with real-time quality control. Developmentally tailored assessments will have stable sensitivity and construct validity across childhood and adolescence, minimize participant burden, capture even subtle changes in SU, mental health, neurocognition, development, and environment, and employ novel bioassays and passive data collection from mobile devices. The retention plan builds on the experience of our investigators to ensure success. This application describes the ABCD-USA Coordinating Center (CC) which will: provide overall administrative and logistical support and scientific integration fr the consortium; establish and implement procedures for core protocols, participant recruitment and retention, and data quality control; provide initial and ongoing training of personnel for standardization; monitor cohort attributes, recruiting and retention practices, data quality, and consortium-wide consistency in real time, and monitor progress toward benchmarks and timelines. CC will ensure adherence to ethical standards and cultural sensitivity of research, and establish and implement policies for dispute resolution, internal and external data sharing, and publication. CC organizes and provides logistical support for meetings and teleconferences of the consortium, steering committee, scientific advisory board and workgroups as well as for educational, scientific, outreach, and dissemination events. By design, CC processes are flexible for problem resolution and incorporation of emerging scientific opportunities. We provide transparent study updates to the public via the web, and a well-managed and fully annotated repository of data for timely sharing. Importantly, we provide training and mentoring to developing scientists in the drug abuse area.