Institutional Center Cores for Advanced Neuroimaging

描述(申请人提供)：本提案的总体目标是建立NINDS机构中心核心设施，以增强明尼苏达大学磁共振研究中心(CMRR)现有的独特资源，用于生物医学成像，以最大限度地利用这些资源，并最大限度地影响NINDS资助的大量正常脑功能和神经疾病研究项目。这一目标是基于这样一个前提，即过去20年的发展已经产生了大量的磁共振(MR)技术，如功能脑成像(FMRI)、神经化学光谱、灌注成像、扩散成像等，这些技术为人类大脑的研究和人类疾病状态的动物模型提供了不可或缺的、否则无法获得的测量能力。然而，这些技术的最佳使用需要先进的仪器、独特的专业知识和复杂的辅助功能，其中包括使用经典技术(如电生理学和组织学)和其他成像方式(如PET)进行补充测量。在单个实验室中，几乎不可能获得这些仪器和方法，特别是在尖端，需要在自旋物理、射频工程、信号和图像处理以及脑科学领域进行跨学科互动。这笔赠款的目的是在CMRR的合作、多学科和互动的研究环境中提供这种机会，以丰富NINDS资助的大量正在进行的研究项目的有效性并促进新的研究方向。

DESCRIPTION (provided by applicant): The general aim of this proposal is to establish NINDS Institutional Center Core facilities that will augment the unique resources that exist at the Center for Magnetic Resonance Research (CMRR), University of Minnesota, for biomedical imaging, so as to maximize their utilization and impact on a large number of NINDS funded research projects on normal brain function and neurological disorders. This aim is based on the premise that developments in the last two decades have generated a plethora of magnetic resonance (MR) techniques, such as functional brain imaging (fMRI), neurochemical spectroscopy, perfusion imaging, diffusion imaging etc., that provide indispensable and otherwise unavailable measurement capabilities for studies of the brain in humans and in animal models of human diseased states. However, optimal use of these techniques requires advanced instrumentation, unique expertise, and complex auxiliary capabilities that include complementary measurements employing classical techniques (e.g. electrophysiology, and histology) and other imaging modalities such as PET. Access to these instrumentation and methodologies, especially at the cutting-edge, is virtually impossible in individual labs and requires interdisciplinary interactions in the area of spin-physics, RF engineering, signal and image processing, and brain sciences. The aim of this grant is to provide this access within the cooperative, multidisciplinary, and interactive research environment of CMRR, so as to enrich the effectiveness of and promote new research directions in a large number of ongoing NINDS funded research projects.