Rush Center of Excellence on Disparties in HIV and Aging (CEDHA)

描述(由申请人提供)：拉什艾滋病毒与老龄化差异英才中心(Rush CEDHA)的总体目标是提供一个基础设施，以支持合作的多学科流行病学研究，重点是了解和消除艾滋病毒与老龄化相关后果中的种族差异。拟建的中心将把少数群体健康和健康差距研究整合并集中到一个跨学科和跨学科的单一企业中。它有四个核心和三个相关的研究项目，以支持中心的目标。行政核心将为CEDHA作为一个整体提供科学领导。研究核心将收集有和没有感染艾滋病毒的老年人(50岁)的年度认知和运动功能数据、心理社会风险因素、合并症和生物标本，并将它们与种族、性别和社会经济地位相匹配的65-90岁未感染艾滋病毒的人的现有数据进行比较。该核心产生的数据将用于支持两个研究项目和一个试点项目，重点是艾滋病毒中的炎症和免疫衰老。项目1将收集核磁共振数据和血清 来自研究核心的受试者的炎症标志物，以及关于年龄、种族和艾滋病毒炎症之间关系的测试假设。项目2将测量免疫扰动和淋巴细胞中免疫衰老的标记物，以估计艾滋病毒导致的年龄相关衰老加速，并测试免疫扰动中的种族差异导致携带艾滋病毒的非裔美国人早期免疫衰老的假设。试点项目1将进行为期12周的随机、双盲、安慰剂对照试验，以探索鱼油调节艾滋病毒衰老相关炎症和免疫衰老参数的安全性并评估其效果。研究培训/教育核心将集中健康差距研究方面的教育努力，并开发一个研究培训部分，指导对健康差距感兴趣的早期职业调查人员。社区参与/外联核心将提供广泛的教育方案，以支持外联和招募少数群体参加研究，并将研究结果传播回经历健康差距的社区。

DESCRIPTION (provided by applicant): The overall goal of the Rush Center of Excellence on Disparities in HIV and Aging (Rush CEDHA) is to provide an infrastructure to support collaborative, multidisciplinary epidemiologic research focused on understanding and eliminating racial disparities in the aging-related consequences of HIV. The proposed Center will integrate and centralize minority health and health disparities research into a single interdisciplinary and trans-disciplinary enterprise. It has four Cores and three related research projects to support the goals of the Center. The Administrative Core will provide scientific leadership to the CEDHA as a whole. The Research Core will collect annual cognitive and motor function data, psychosocial risk factors, co-morbidities, and biospecimens in older adults (>50 years) with and without HIV infection, and compare them to existing data from HIV-uninfected persons age 65-90 matched on race, gender, and socioeconomic status. The data generated by this Core will be used to support two research projects and one pilot project focused on inflammation and immune senescence in HIV. Project 1 will collect MRI data and serum inflammatory markers on subjects from the Research Core, and test hypotheses concerning the relationships among age, race, and inflammation in HIV. Project 2 will measure immune perturbations and markers of immune senescence in lymphocytes to estimate the age-associated acceleration in aging due to HIV, and test the hypothesis that racial differences in immune perturbations lead to early immune senescence in African Americans with HIV. Pilot project 1 will conduct a 12-week, randomized, double-blind, placebo-controlled trial to explore the safety and estimate the effect offish oil to modulate parameters of aging-related inflammation and immune senescence in HIV. The Research Training/Education Core will centralize education efforts in health disparities research and develop a research training component to mentor early career investigators interested in health disparities. The Community Engagement/Outreach Core will provide a wide range of educational programs to support outreach and recruitment of minorities into studies and disseminate research findings back to the communities experiencing the health disparities.