Rush Center of Excellence on Disparties in HIV and Aging (CEDHA)

描述（由申请人提供）：拉什艾滋病毒和老龄化差异卓越中心（拉什CEDHA）的总体目标是提供一个基础设施，以支持协作，多学科流行病学研究，重点是了解和消除艾滋病毒与老龄化相关后果的种族差异。该中心将整合和集中少数民族健康和健康差异研究，成为一个单一的跨学科和跨学科企业。它有四个核心和三个相关的研究项目来支持中心的目标。行政核心将为整个委员会提供科学领导。研究核心将收集感染和未感染艾滋病毒的老年人（50岁至50岁）的年度认知和运动功能数据、社会心理风险因素、合并症和生物标本，并将其与65-90岁未感染艾滋病毒的人的现有数据进行比较，这些数据与种族、性别和社会经济地位相匹配。该核心产生的数据将用于支持两个研究项目和一个试点项目，重点是艾滋病毒的炎症和免疫衰老。项目1收集MRI数据和血清

DESCRIPTION (provided by applicant): The overall goal of the Rush Center of Excellence on Disparities in HIV and Aging (Rush CEDHA) is to provide an infrastructure to support collaborative, multidisciplinary epidemiologic research focused on understanding and eliminating racial disparities in the aging-related consequences of HIV. The proposed Center will integrate and centralize minority health and health disparities research into a single interdisciplinary and trans-disciplinary enterprise. It has four Cores and three related research projects to support the goals of the Center. The Administrative Core will provide scientific leadership to the CEDHA as a whole. The Research Core will collect annual cognitive and motor function data, psychosocial risk factors, co-morbidities, and biospecimens in older adults (>50 years) with and without HIV infection, and compare them to existing data from HIV-uninfected persons age 65-90 matched on race, gender, and socioeconomic status. The data generated by this Core will be used to support two research projects and one pilot project focused on inflammation and immune senescence in HIV. Project 1 will collect MRI data and serum inflammatory markers on subjects from the Research Core, and test hypotheses concerning the relationships among age, race, and inflammation in HIV. Project 2 will measure immune perturbations and markers of immune senescence in lymphocytes to estimate the age-associated acceleration in aging due to HIV, and test the hypothesis that racial differences in immune perturbations lead to early immune senescence in African Americans with HIV. Pilot project 1 will conduct a 12-week, randomized, double-blind, placebo-controlled trial to explore the safety and estimate the effect offish oil to modulate parameters of aging-related inflammation and immune senescence in HIV. The Research Training/Education Core will centralize education efforts in health disparities research and develop a research training component to mentor early career investigators interested in health disparities. The Community Engagement/Outreach Core will provide a wide range of educational programs to support outreach and recruitment of minorities into studies and disseminate research findings back to the communities experiencing the health disparities.