Hyperandrogenemia, Diet and Female Reproductive Health

描述（由申请人提供）：俄勒冈州健康与科学大学（OHSU）的俄勒冈州国家灵长类动物研究中心（ONPRC）提出了一个生殖和不孕不育研究专业合作中心（U 54），该中心致力于高雄激素血症和肥胖对女性生殖健康的影响。一个跨学科的翻译项目旨在区分过量雄激素暴露和典型西式饮食（WSD，高脂肪和果糖含量）引起的代谢变化对以下方面的影响：（1）下丘脑-垂体-卵巢-生殖道轴，以及脂肪组织;（2）对生育能力的影响;（3）治疗效果是否可逆。三个研究项目使用非人灵长类动物模型，一个项目关注多囊卵巢综合征（PCOS）瘦女性的特定人群。 项目I，“代谢和神经内分泌对高雄激素血症和饮食的反应”，由J.卡梅隆通过匹兹堡大学和K. ONPRC的格罗夫。项目二，“卵巢和子宫结构-功能：雄激素和饮食的影响”，是R。斯托弗和 O. Slayden，ONPRC.项目三，“雄激素和饮食对脂肪功能的影响”，涉及C。Roberts和他在ONPRC的同事。项目IV，“雄激素过量作为PCOS妇女脂肪生成功能障碍的机制”，包括一个与临床专家（D。杜梅西克湾Chazenbalk）在洛杉矶的加州大学。项目I-III将由非人灵长类动物（NHP）核心（O。Slayden，主管）作为封闭资源运行。该核心将维持四个年轻雌性恒河猴治疗组（对照组、睾酮或T治疗组、WSD治疗组和T + WSD）四年，最终进行生育力试验。在2005年，T和水务署的行动将被审查的可逆性。此外，行政核心（R。Stouffer，P.I.），外展核心（D。Gordon和M. Zelinski）将促进SCCPIR中心内部和中心之间的互动，并提高公众对生殖健康研究的认识和理解。重要的是，新的信息将积累雄激素和饮食相关因素的作用，单独和组合，有关的病因和治疗生育障碍，如PCOS。

DESCRIPTION (provided by applicant): The Oregon National Primate Research Center (ONPRC) at the Oregon Health & Science University (OHSU) proposes a Specialized Cooperative Center in Reproduction and Infertility Research (U54) that addresses the effects of hyperandrogenemia and obesity on female reproductive health. An interdisciplinary, translational program is designed to discern between the effects of excess androgen exposure and metabolic changes due to a typical Western-style diet (WSD, high fat and fructose content) on: (1) the hypothalamus-pituitary-ovary-reproductive tract axis, as well as adipose tissue; (2) the impact on fertility; and (3) if the treatment effects are reversible. Three research projects ue the nonhuman primate model, and one project focuses on the specific population of lean women with polycystic ovarian syndrome (PCOS). Project I, "Metabolic and Neuroendocrine Responses to Hyperandrogenemia and Diet", is directed by J. Cameron, via a consortium with the University of Pittsburgh and K. Grove at ONPRC. Project II, "Ovarian and Uterine Structure-Function: Influence of Androgen and Diet", is a collaboration between R. Stouffer and O. Slayden, ONPRC. Project III, "Effects of Androgen and Diet on Adipose Function," involves C. Roberts and colleagues at ONPRC. Project IV, "Androgen Excess as a Mechanism for Adipogenic Dysfunction in PCOS Women," incorporates a consortium with clinical experts (D. Dumesic, G. Chazenbalk) at the University of California, Los Angeles. Projects l-lll will be supported by a nonhuman primate (NHP) Core (O. Slayden, Supervisor) operating as a closed resource. This Core will maintain four treatment groups of young, female rhesus monkeys (controls, testosterone or T-treated, WSD-treated, and T + WSD) for four years, culminating in a fertility trial. In Year 05, reversibility of T and WSD actions will be examined. In addition, the Administrative Core (R. Stouffer, P.I.), and Outreach Core (D. Gordon and M. Zelinski) will promote interactions within and among SCCPIR Centers and increase public awareness and understanding of reproductive health research. Important, new information will accrue on the actions of androgen and diet-related factors, individually and in combination, relevant to the etiology and treatment of fertility disorders, such as PCOS.