A Laser Microbeam Biotechnology Resource

描述(由申请人提供)：激光微束和医学计划(LAMMP)，致力于激光和光学在生物学和医学中的使用。LAMP位于加州大学欧文分校的贝克曼激光研究所和医疗诊所内，这是一个跨学科的生物医学研究、教学和临床设施。LAMP的活动范围从基础科学和技术开发到临床转化性研究。这是通过将最先进的生物光子学技术与细胞和组织工程、组织病理学、临床前动物模型和临床护理的专门资源设施相结合来实现的。LAMPS项目包括生物光子学建模和技术开发、基础科学研究、仪器原型以及人体和动物模型的设备测试。由于我们的设施、资源和专业知识，我们能够迅速将新概念和技术从黑板转移到工作台和床边。在LAMP的第七次续订申请中，我们继续通过推进几项新技术和高影响力的合作来改造我们的中心。我们建议将我们的活动整合到4个主要的技术研发领域：虚拟光子学技术(VPT)、显微镜和微束技术(MMT)、多模内窥镜技术(MET)和漫反射光学技术(DOT)。为每个研发核心提出了具体的目标，这些目标将导致几种最先进的技术、仪器和 计算方法。四个研发核心一起包含互补的、相互依赖的方法，用于定量描述、成像和扰动细胞和组织的结构和生化功能，具有可扩展的分辨率和从微米到厘米的深度灵敏度。我们的广泛目标是通过协作、服务、培训和传播活动推动这些技术的发展，使它们成为广泛可用的，使解决生物学和医学中重要问题的方法成为可能。

DESCRIPTION (provided by applicant): The Laser Microbeam and Medical Program (LAMMP), is dedicated to the use of lasers and optics in Biology and Medicine. LAMMP is located within the Beckman Laser Institute and Medical Clinic, an interdisciplinary biomedical research, teaching, and clinical facility at the University of California, Irvine. LAMMP activities span from basic science and technology development to clinical translational research. This is accomplished by combining state of the art Biophotonics technologies with specialized resource facilities for cell and tissue engineering, histopathology, pre-clinical animal models, and clinica care. LAMMP programs include Biophotonics modeling and technology development, basic science studies, instrument prototyping, and device testing in humans and animal models. Because of our facilities, resources, and expertise, we are able to rapidly move new concepts and technologies from blackboard to bench-top to bedside. In this seventh renewal application of LAMMP, we continue to transform our center by advancing several new technologies and high-impact collaborations. We propose to consolidate our activities into 4 major areas of Technology Research and Development (TR&D): Virtual Photonics Technologies (VPT), Microscopy and Microbeam Technologies (MMT), Multimodality Endoscopic Technologies (MET), and Diffuse Optics Technologies (DOT). Specific Aims are proposed for each TR&D core that will result in the development of several state-of-the-art technologies, instruments, and computational methods. Together, the four TR&D cores contain complementary, inter-dependent approaches for quantitatively characterizing, imaging, and perturbing structure and biochemical function in cells and tissues with scalable resolution and depth sensitivity ranging from micrometers to centimeters. Our broad goal is to advance these technologies through collaboration, service, training, and dissemination activities so they become widely-available, enabling methods for solving important problems in Biology and Medicine.