Sources, Transport, Exposure and Effects of PFASs (STEEP)

核心摘要/摘要 由URI领导的STEEP（PFASs的来源、运输、暴露和影响）提议帮助超级基金 研究计划（SRP）在解决新出现的和不断扩大的问题，多氟烷基和全氟烷基 PFASs污染。PFASs是一种工业化合物， 20世纪50年代，由于其独特的防油和防水性能，在无数产品中使用。环境 在过去的十年中，才开始确定其传播和对人类健康的影响。 因此，美国环境保护署对PFASs污染饮用水的限制仍然存在。 自2009年首次发布以来，暂定。此外，在最近发布的2015年ToxProfile草案中， 有毒物质和疾病登记处（ATSDR）强调了人体PFAS的许多不确定性 健康影响，因此忽略了最近关于PFAS暴露对人类健康产生不利影响的报告 因此，迫切需要改进风险特征。 行政核心（AC）是STEEP的中心枢纽，通过 在STEEP项目的研究和交流中发挥主任的作用，并负责日常管理， 核心活动。它的主要作用是确保STEEP运行良好，并产生综合科学，培训， 沟通和参与，使SRP和利益攸关方受益。STEEP将由Rainer Lohmann领导， 哲学博士、中心主任（罗得岛大学，URI）和Philippe Grandjean，医学博士，D.M.Sc，Center Co- 主任（哈佛大学，胡），谁将提供中心整合，愿景和有效的领导。他们将 由中心经理Frank Baker（URI）提供支持，他将监督日常运营和工作 的中心。咨询委员会将每两个月接受一次内部咨询委员会的指导， 外部咨询委员会（EAC）每年作为一个全天务虚会的一部分。 URI致力于URI STEEP中心的成功，并将资助教师任命， 相关的新兴污染物领域，以进一步加强中心的专业知识，支持中心经理，基金 2个额外的少数民族研究生助学金和资金，以支持更多的研究生 活动URI STEEP将组织2020年秋季URI荣誉座谈会，重点关注新兴污染物 让学术界和公众都能接触到 AC将通过以下方式履行其承诺，确保URI领导的STEEP取得成功 具体目标： 具体目标1：创建一个STEEP组织，及时响应机会， 挑战和评价。 具体目标2：确保通过定期的研究项目和核心的成功整合 项目和核心领导人的会议，以及IAC和EAC的评估。 具体目标3：为利益相关者和社区提供相关的业务见解和工具。

CORE SUMMARY/ABSTRACT The URI-led STEEP (Sources, Transport, Exposure and Effects of PFASs) proposes to aid the Superfund Research Program (SRP) in addressing the emerging and expanding problem of poly- and perfluorinated alkyl substances (PFASs) contamination. PFASs are industrial compounds that have been manufactured since the 1950s for use in myriad products due to their unique oil and water repellent properties. The environmental dissemination and the human health effects have only begun to be characterized over the previous decade. Thus, U.S. Environmental Protection Agency limits for PFASs contamination of drinking water remain provisional since first published in 2009. Also, in the recently released 2015 draft ToxProfile, the Agency for Toxic Substances and Disease Registry (ATSDR) stressed a number of uncertainties as to PFASs human health impacts and therefore disregarded recent reports on adverse human health effects at PFASs exposures commonly occurring in the U.S. Thus, the need for improved risk characterization is urgent. The Administrative Core (AC) is the central hub of STEEP, integrated with the rest of center through the Director’s role in active STEEP Project research and communication, and runs the day-to-day management of Core activities. Its main role is to ensure STEEP runs well and produces integrated science, training, communication, and engagement of benefit to SRP and stakeholders. STEEP will be led by Rainer Lohmann, Ph.D., Center Director (University of Rhode Island, URI) and Philippe Grandjean, M.D., D.M.Sc, Center Co- Director (Harvard University, HU), who will provide center integration, vision, and effective leadership. They will be supported by Frank Baker (URI), Center Manager, who will oversee the day-to-day operation and workings of the Center. The AC will be guided by an Internal Advisory Committee (IAC) on a bimonthly basis, and by an External Advisory Committee (EAC) annually as part of a full-day retreat. URI is committed to the success of the URI STEEP Center and will fund a faculty appointment in a related emerging contaminants field to further strengthen Center expertise, support the Center Manager, fund 2 additional minority graduate student assistantships and funds to support additional graduate student activities. URI STEEP will organize the Fall 2020 URI Honors Colloquium focusing on emerging contaminants with access for the academic community and the public. The AC will fulfill its commitment to ensure the success of the URI-led STEEP through the following Specific Aims: Specific Aim 1: Create a STEEP organization that responds in a timely fashion to opportunities, challenges, and evaluations. Specific Aim 2: Ensure successful integration of Research Projects and Cores through regular meetings of Project and Core leaders coupled with evaluations from IAC and EAC. Specific Aim 3: Provide relevant operational insights and tools for stakeholders and communities.