How do stem cells get specified during embryonic muscle development?
How do stem cells get specified during embryonic muscle development?
批准号:
DP240101647
负责人:
Prof Peter Currie
金额:
$44.26万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2024
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2024-01-01 至 2026-12-31
中文摘要
该项目旨在研究肌肉干细胞在胚胎中首次形成的机制。该项目有望产生关于胚胎肌节中细胞类型模式的机制的新知识。该项目的预期成果包括揭示肌节中细胞类型特化的发育机制,特别是干细胞的产生。这应该提供显著的益处,因为它将告知在第一种情况下可以制造多长寿命的组织驻留干细胞,这对于在动物体外按需制造干细胞和在活组织中操纵干细胞至关重要。
英文摘要
This project aims to investigate the mechanisms by which muscle stem cells first form in the embryo. This project expects to generate new knowledge on the mechanism that patterns cell types in the embryonic myotome. Expected outcomes of this project include uncovering the developmental mechanisms of cell type specification in the myotome with specific reference to the generation of stem cells. This should provide significant benefits as it will inform how long lived tissue resident stem cells can be made in the first instance, knowledge that is critical for making stem cells on demand outside the animal and manipulating stem cells in living tissue.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
The developmental and evolutionary origins of vertebrate fins and limbs.
-
批准号:DP240102156
-
项目类别:Discovery Projects
-
资助金额:$41.26万
-
财政年份:2024
-
负责人:Prof Peter Currie
-
依托单位:
Developing macrophage-based technologies for tissue regeneration
-
批准号:LP210200908
-
项目类别:Linkage Projects
-
资助金额:$61.71万
-
财政年份:2023
-
负责人:Prof Peter Currie
-
依托单位:
Fins to Limbs: Investigating the Evolution of complex Limb Musculature
-
批准号:DP200103219
-
项目类别:Discovery Projects
-
资助金额:$29.33万
-
财政年份:2020
-
负责人:Prof Peter Currie
-
依托单位:
How limbs evolved from fins: the role of somite cells
-
批准号:DP190102204
-
项目类别:Discovery Projects
-
资助金额:$26.67万
-
财政年份:2019
-
负责人:Prof Peter Currie
-
依托单位:
Genetic basis for skeletal muscle formation and regeneration in development and disease
-
批准号:nhmrc : 1136567
-
项目类别:Research Fellowships
-
资助金额:$59.23万
-
财政年份:2018
-
负责人:Prof Peter Currie
-
依托单位:
Defining the molecular regulation of muscle stem cell action during organ growth
-
批准号:nhmrc : GNT1139253
-
项目类别:Project Grants
-
资助金额:$73.83万
-
财政年份:2018
-
负责人:Prof Peter Currie
-
依托单位:
Genetic basis for skeletal muscle formation and regeneration in development and disease
-
批准号:nhmrc : GNT1136567
-
项目类别:Research Fellowships
-
资助金额:$87.6万
-
财政年份:2018
-
负责人:Prof Peter Currie
-
依托单位:
Defining the molecular regulation of muscle stem cell action during organ growth
-
批准号:nhmrc : 1139253
-
项目类别:Project Grants
-
资助金额:$49.92万
-
财政年份:2018
-
负责人:Prof Peter Currie
-
依托单位:
Mechanisms of muscle stem cell action in injury and disease.
-
批准号:nhmrc : 1104190
-
项目类别:Project Grants
-
资助金额:$55.9万
-
财政年份:2016
-
负责人:Prof Peter Currie
-
依托单位:
Evolution of the dermomyotome in vertebrates
-
批准号:DP160104427
-
项目类别:Discovery Projects
-
资助金额:$27.98万
-
财政年份:2016
-
负责人:Prof Peter Currie
-
依托单位:
Mechanisms of muscle stem cell action in injury and disease.
-
批准号:nhmrc : GNT1104190
-
项目类别:Project Grants
-
资助金额:$81.26万
-
财政年份:2016
-
负责人:Prof Peter Currie
-
依托单位:
Molecular mechanisms that generate muscle cell type diversity.
-
批准号:DP150103820
-
项目类别:Discovery Projects
-
资助金额:$22.66万
-
财政年份:2015
-
负责人:Prof Peter Currie
-
依托单位:
Genetic basis for skeletal muscle formation in development and disease.
-
批准号:nhmrc : 1041885
-
项目类别:Research Fellowships
-
资助金额:$50.13万
-
财政年份:2013
-
负责人:Prof Peter Currie
-
依托单位:
Modelling Laminin mediated adhesion and congenital muscular dystrophy in Zebrafish
-
批准号:nhmrc : 1045467
-
项目类别:Project Grants
-
资助金额:$39.08万
-
财政年份:2013
-
负责人:Prof Peter Currie
-
依托单位:
Molecular mechanisms that generate and activate muscle stem cells during growth and disease.
-
批准号:nhmrc : 1045468
-
项目类别:Project Grants
-
资助金额:$39.75万
-
财政年份:2013
-
负责人:Prof Peter Currie
-
依托单位:
Generating a targeted mutation resource in zebrafish
-
批准号:LP120100281
-
项目类别:Linkage Projects
-
资助金额:$38.11万
-
财政年份:2012
-
负责人:Prof Peter Currie
-
依托单位:
The role of scube gene function in hedgehog signal transduction
-
批准号:nhmrc : 1027862
-
项目类别:Project Grants
-
资助金额:$36.49万
-
财政年份:2012
-
负责人:Prof Peter Currie
-
依托单位:
Genetic and molecular basis of appendicular muscle formation
-
批准号:DP110101482
-
项目类别:Discovery Projects
-
资助金额:$19.68万
-
财政年份:2011
-
负责人:Prof Peter Currie
-
依托单位:
The development and evolution of the pelvic girdle in basal gnathostomes
-
批准号:DP1096002
-
项目类别:Discovery Projects
-
资助金额:$19.85万
-
财政年份:2010
-
负责人:Prof Peter Currie
-
依托单位:
Molecular and cellular basis for muscle regeneration in zebrafish.
-
批准号:nhmrc : 514913
-
项目类别:NHMRC Project Grants
-
资助金额:$36.08万
-
财政年份:2008
-
负责人:Prof Peter Currie
-
依托单位:
国内基金
海外基金
登录
查看更多内容
Janus磁性微纳马达头部尾部功能单元的精细调控实现低PMS浓度触发DO活化形成自由基(SO4•-和•OH)与非自由基(1O2)
-
批准号:52572315
-
项目类别:面上项目
-
资助金额:50.00万元
-
批准年份:2025
-
负责人:李嘉
-
依托单位:
复合菌剂在高DO下的好氧反硝化脱氮机制及工艺调控研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2024
-
负责人:周月明
-
依托单位:
铁皮石斛响应内生真菌DO14效应因子的DcMYB6/9调控葡甘聚糖合成的分子机制
-
批准号:32470403
-
项目类别:面上项目
-
资助金额:50.00万元
-
批准年份:2024
-
负责人:吴令上
-
依托单位:
内生真菌DO14多糖PPF30调控铁皮石斛葡甘聚糖生物合成的机制
-
批准号:LZ23H280001
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2023
-
负责人:吴令上
-
依托单位:
基于捕获“Do not eat me”信号的肺癌异质性分子功能可视化及机理研究
-
批准号:92259102
-
项目类别:重大研究计划
-
资助金额:60.00万元
-
批准年份:2022
-
负责人:许川
-
依托单位:
基于达文波特星形酵母Do18强化发酵的糟带鱼生物胺生物调控机制
-
批准号:--
-
项目类别:青年科学基金项目
-
资助金额:30万元
-
批准年份:2022
-
负责人:涂传海
-
依托单位:
基于PO-DGT原理的沉积物微界面pH-DO-磷-重金属的精细化同步成像技术研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:54万元
-
批准年份:2022
-
负责人:韩超
-
依托单位:
CD38/cADPR信号通路异常促逼尿肌过度活动(DO)发生的分子机制及干预措施研究
-
批准号:81770762
-
项目类别:面上项目
-
资助金额:56.0万元
-
批准年份:2017
-
负责人:郑霁
-
依托单位:
USP2介导RagA去泛素化稳定肿瘤细胞“Do not eat me”信号的机制研究
-
批准号:81773040
-
项目类别:面上项目
-
资助金额:62.0万元
-
批准年份:2017
-
负责人:金国祥
-
依托单位:
抑制骨细胞来源Sclerostin蛋白对颌面部DO成骨的协同促进作用
-
批准号:81771104
-
项目类别:面上项目
-
资助金额:56.0万元
-
批准年份:2017
-
负责人:钱玉芬
-
依托单位: