Quantitative Behavioral Assessment & Rehabilitation (QBAR)

定量行为评估和康复核心（QBAR）继续建立在四个实验室的基础上 在健康学院内提供最先进的行为功能测量（例如， 3-D运动学、动力学和肌电图）和康复干预（运动、约束诱导 运动和强化任务导向上肢训练）。当前 实践中，临床医生可用的测量和干预框架在理论上是不够的， 确定中风后患者的相关缺陷并规定有效的干预是不切实际的。我们 我认为康复必须朝着这样一种模式发展：a）一个人的运动控制系统的健康 可以被测定，B）可以鉴定特定的缺陷，c）可以使用特定的治疗来靶向缺陷， 以及d）定量测量可以提供治疗前和治疗后状态的评估。该核心支持 研究人员通过五个具体目标制定测量和干预框架， 包括：1）定量行为评估，使研究人员能够研究如何衡量大脑 可塑性和行为可用于指导和个性化康复和/或恢复治疗。核心 该角色的服务包括：运动捕捉和肌电图，用于精确测量运动和肌肉 活动;用耗氧量测量的能量学;测量活动的加速度计装置 例如行走和偏瘫手臂使用;单个关节的力量和功率的神经肌肉测量; 临床测量;和动物行为分析设备。2)修复，使COBRE调查人员能够 研究中风后可塑性的经验依赖性，通过标准化经验来优化 通过使用当前最先进的方法和/或开发的恢复疗法的治疗效果 新的工具或方法。在这个角色的核心服务包括：运动康复;上肢康复; 以及适合于动物中风模型的动物模型康复。3)基于理论的结果的发展 测量（行为"生物标志物"）和形成大型定量行为数据集， 国际数据共享。4)为所有COBRE调查员提供多学科项目指导。第五章） 促进QBAR核心作为中风恢复研究的领先的地方/国家/国际资源。 COBRE基金将帮助支持训练有素的技术人员进行关键研究和培训 QBAR实验室内的职能，以及具有专业知识的专业人员， 康复科学、运动和能量学以及使用独特动物模型的资源导师。qbar 我将为所有COBRE下属的调查人员提供指导和咨询，特别是那些没有初级 行为/功能和康复测量方面的专业知识。总体目标是利用QBAR， 被公认为来自南卡罗来纳州和其他地方的中风康复研究人员的"首选"场所。

The Quantitative Behavioral Assessment & Rehabilitation Core (QBAR) continues to build on four laboratories within the College of Health Professions to provide state-of-the-art measurements of behavioral function (e.g., 3-D kinematics, kinetics and electromyography) and rehabilitation interventions (locomotor, constraint-induced movement and intensive task-oriented upper extremity training) in hemiparetic post-stroke patients. In current practice, the measurement and intervention framework available to clinicians is theoretically insufficient and impractical to determine relevant deficits of a post-stroke patient and prescribe efficacious interventions. We believe that rehabilitation must move toward a model where: a) the health of a person’s motor control system can be assayed, b) specific deficits can be identified, c) specific treatments can be used to target the deficits, and d) quantitative measures can provide assessment of pre- and post-treatment states. This core supports investigators in their development of measurement and intervention frameworks via five specific aims that encompass: 1) Quantitative Behavioral Assessment, enabling investigators to study how measures of brain plasticity and behavior can be used to guide and individualize rehabilitation and/or restorative therapies. Core services in this role include: motion capture and electromyography for precise measures of motion and muscle activity; energetics as measured by oxygen consumption; accelerometer-based devices for measuring activities such as walking and hemiparetic arm use; neuromuscular measures of strength and power of individual joints; clinical measures; and animal behavioral assay equipment. 2) Rehabilitation, enabling COBRE investigators to study the experience-dependent nature of post-stroke plasticity by standardizing experience to optimize the treatment effects of restorative therapies through the use of current state-of-the-art methods and/or developing novel tools or methods. Core services in this role include: locomotor rehabilitation; upper extremity rehabilitation; and animal model rehabilitation appropriate to animal stroke models. 3) Development of theory-based outcome measures (behavioral “biomarkers”) and formation of large quantitative behavioral data sets for local, national and international data sharing. 4) Multidisciplinary programmatic mentoring of all COBRE investigators. 5) Promotion of the QBAR Core as a leading local/national/international resource for stroke recovery research. COBRE funds will help support highly trained technical personnel to perform critical research and training functions within the QBAR labs, as well as professional personnel with specialized expertise to serve as Resource Mentors in rehabilitation science, exercise and energetics, and use of unique animal models. QBAR will provide mentoring and consultation to all COBRE-affiliated investigators, especially those without primary expertise in measurement of behavior/function and rehabilitation. The overall goal is for QBAR to be utilized and recognized as the “go-to” place for stroke rehabilitation researchers from across South Carolina and elsewhere.