CSHL 2020 PARP Family & ADP-Ribosylation Conference

冷泉港实验室会议 PARP家族与ADP-核糖基化 2020年4月1日至4日 项目摘要 该提案寻求支持将于2015年12月15日在纽约举行的关于“PARP家族和ADP核糖基化”的会议。 冷泉港实验室（CSHL），2020年4月1日至4日。ADP-核糖基化是一种翻译后 由单和多（ADP-核糖基）转移酶家族（PARP）催化的蛋白质修饰 家庭）。PARP蛋白具有催化ADP-核糖转移的内在酶活性 通过从烟酰胺腺嘌呤二核苷酸（NAD+）向靶蛋白上转移ADPR（ADPR）单位，从而调节它们的表达， 活动最近的研究强调了ADP-核糖基化反应在细胞内的多样性和重要作用。 生理和病理状态下的细胞功能。这对PARP和ADP来说是一个激动人心的时刻- 核糖基化，三种FDA批准的PARP抑制剂在临床上用于治疗癌症， 其他有前景的应用正在探索中。这次会议将汇集该领域的领导人， 初级教师，博士后研究员和研究生，介绍，审查和讨论当前的研究， PARP和ADP-核糖基化，特别是当它们与癌症、炎症和代谢紊乱有关时。 PARP和ADP-核糖基化在广泛的生理过程（例如，DNA 修复，基因组完整性的维护，代谢，激素信号传导，基因调控和RNA生物学） 和病理生理过程（癌症、炎症、应激、代谢疾病和衰老）。这种独特 及时的会议将使研究不同系统并使用不同方法的科学家聚集在一起。 本次会议的目的是介绍，审查和讨论目前的研究涵盖（1）历史领域 PARP领域的重要性，如核PARP在DNA修复中的作用，以及新出现的作用， 基因调控和RNA生物学中的核PARP;（2）非核PARP和单（ADP-核糖基） 转移酶;（3）与PARP功能性相互作用或控制NAD+代谢的蛋白质;（4）广泛的 PARP发挥作用的生物系统和疾病状态的范围，（5）PARP的治疗效用 抑制剂治疗疾病，如癌症，和（6）所需的方法学进展，以解决关键的 在外地留下的问题。此外，本次会议还将为以下人员提供职业发展机会： 培训人员和一个论坛，讨论当前的问题和规划未来的PARP领域。 每次会议将由该领域的一位顶尖科学家主持。口头报告将由 特邀嘉宾以及从摘要中选出的发言者。其中包括毕业生 学生，博士后研究员和初级教师，旨在最大限度地纳入年轻的研究人员， 在生物医学领域代表性不足的群体。特别重要的是海报会议， 许多与会者可以在有利于非正式讨论的气氛中介绍他们的工作。我们 预计约有175人参加，其中绝大多数人将展示海报或演讲。总的来说，这次会议- 在PARP领域的第一次会议-将支持强有力的思想交流和促进合作。

Cold Spring Harbor Laboratory Conference on The PARP Family and ADP-ribosylation April 1 - 4, 2020 Project Summary This proposal seeks support for a meeting on “The PARP Family and ADP-ribosylation” to be held at Cold Spring Harbor Laboratory (CSHL) on April 1 - 4, 2020. ADP-ribosylation is a posttranslational modification of proteins catalyzed by a family of mono- and poly(ADP-ribosyl) transferase enzymes (the PARP family). PARP proteins possess an intrinsic enzymatic activity that catalyzes the transfer of ADP-ribose (ADPR) units from nicotinamide adenine dinucleotide (NAD+) onto target proteins, thereby modulating their activities. Recent studies have highlighted the diverse and important roles of ADP-ribosylation reactions in cellular functions in physiological and pathological states. This is an exciting time for PARPs and ADP- ribosylation, with three FDA-approved PARP inhibitors being used in the clinic for the treatment of cancer and other promising applications being explored. This meeting will assemble leaders in the field, together with junior faculty, postdoctoral fellows and graduate students, to present, review, and discuss current research on PARPs and ADP-ribosylation, especially as they pertain to cancer, inflammation, and metabolic disorders. PARPs and ADP-ribosylation play diverse roles in a broad range of physiological processes (e.g., DNA repair, maintenance of genome integrity, metabolism, hormone signaling, gene regulation, and RNA biology) and pathophysiological processes (cancer, inflammation, stress, metabolic diseases, and aging). This unique and timely meeting will bring together scientists working on different systems and using different approaches. The aims of this meeting are to present, review, and discuss current research covering (1) areas of historical importance to the PARP field, such as the role of nuclear PARPs in DNA repair, as well as emerging roles for nuclear PARPs in gene regulation and RNA biology; (2) non-nuclear PARPs and the mono(ADP-ribosyl) transferases; (3) proteins that functionally interact with PARPs or control NAD+ metabolism; (4) a broad spectrum of biological systems and disease states in which PARPs function, (5) the therapeutic utility of PARP inhibitors in treating diseases, such as cancers, and (6) methodological advances required to address critical remaining questions in the field. In addition, this meeting will provide career development opportunities for trainees and a forum for discussing current issues and planning the future of the PARP field. Each session will be chaired by a leading scientist in the field. Oral presentations will be given by distinguished invited speakers, as well as speakers selected from the abstracts. These will include graduate students, postdoctoral fellows, and junior faculty, aiming for maximal inclusion of young investigators and groups typically underrepresented in the biomedical sciences. Of special importance is the poster session, where many participants can present their work in an atmosphere conducive to informal discussions. We expect about 175 people to attend, with the vast majority presenting a poster or talk. Overall, this meeting - the premier meeting in the PARP field - will support the robust exchange of ideas and promote collaborations.