Neurodevelopment and Environment: From Science to Dissemination and Translation

摘要 此R13应用程序将支持召开Tenr项目的第五次研讨会：“目标环境 和神经发育风险。Tenr项目是领先的儿童环境健康联盟 科学家、卫生专业人员和儿童健康、环境和残疾组织联合起来 他们担心有毒化学物质和污染物会损害儿童的大脑发育，并使儿童 有较高的学习、发育和智力残疾风险。Project Tenr于2015年共同创立 作者：Maureen Swanson，美国学习障碍协会，Irva Hertz-Picciotto博士，The Mind 加州大学戴维斯分校研究所。它的使命是将关于化学品和污染物的科学转化为 损害大脑发育，以促进社区行动和制定健康保护政策， 目标是减少发育障碍和障碍，消除不成比例的暴露于 有色人种儿童和来自低收入家庭或社区的儿童。到目前为止，我们已经出版了四本 发表在同行评议期刊上的文章。第一个是Tenr在环境健康方面的共识声明 观点(Bennett等人，2016)，确定了化学品和污染物暴露的例子 有证据支持他们对儿童学习和发育障碍的贡献，并呼吁 对允许持续暴露于这些和其他神经毒物的监管体系进行彻底改革。 接下来的三份出版物提出了可以减少风险敞口的政策和做法的建议 致：铅(Bellinger等人，《美国医学会儿科杂志》2017)，有机磷农药(Hertz-Picciotto等人，PLOS 医学)和空气污染(佩恩-斯特吉斯等人，Am J Public Health)。Tenr的其他活动有 包括在专业会议、国会简报和州立法听证会上发言。 此外，Tenr的个别成员还撰写或签署了提供科学信息的信件。 与正在讨论的政策或法规相关的。 研讨会将于2019年10月28日至30日在加利福尼亚州奥克兰的海滨酒店举行。我们期待着到场人数 大约45-50名Tenr成员。研讨会的重点是两个主要目标：1)起草、修改或 敲定两到三份目前正在计划或已经起草的手稿；2)发展一门科学 传播和传播计划，以解决即将到来的2020年政策问题。的特定主题 手稿包括：环境贡献引起的神经发育影响，以及 气候变化的后果；邻苯二甲酸盐暴露与神经发育结果的关系；以及 有色人种或低有色人种社区环境化学和污染物暴露的不成比例负担 收入、土著人民或移民与神经发育障碍方面的健康差距有关。

Abstract This R13 application will support convening the fifth workshop for Project TENDR: “Targeting Environmental and NeuroDevelopment Risks.” Project TENDR is an alliance of leading children's environmental health scientists, health professionals, and children's health, environmental, and disabilities organizations united in their concern over toxic chemicals and pollutants that can harm children's brain development, and put children at higher risk for learning, developmental and intellectual disabilities. Project TENDR was co-founded in 2015 by Maureen Swanson, Learning Disabilities Association of America, and Dr. Irva Hertz-Picciotto, The MIND Institute, University of California Davis. Its mission is to translate the science on chemicals and pollutants that harm brain development in order to foster community action and development of health-protective policies, with the goal to reduce developmental impairments and disorders, and to eliminate disproportionate exposures of children of color and children from low-income families or communities. To date, we have published four articles in peer-reviewed journals. The first was the TENDR Consensus Statement in Environmental Health Perspectives (Bennett et al 2016) which identified example chemical and pollutant exposures for which evidence supports their contribution to learning and developmental disabilities in children, and called for an overhaul of the regulatory system that has allowed continuing exposures to these and other neurotoxicants. The next three publications present recommendations for policies and practices that could reduce exposures to: lead (Bellinger et al., JAMA Pediatrics 2017), organophosphate pesticides (Hertz-Picciotto et al., PLos Medicine), and air pollution (Payne-Sturges et al., Am J Public Health). Other activities from TENDR have included speaking at professional conferences, Congressional briefings, and state legislative hearings. Additionally, individual members of TENDR have written or signed letters providing scientific information relevant to policies or regulations that are under discussion. The workshop will take place at the Waterfront Hotel in Oakland, CA, Oct 28-30, 2019. We expect attendance of approximately 45-50 TENDR members. The workshop focus is on two major aims: 1) to draft, revise, or finalize two or three manuscripts that are currently planned or already drafted; 2) to develop a science communication and dissemination plan to address upcoming policy issues for 2020. Specific topics for the manuscripts include: neurodevelopmental impacts arising from the environmental contributions to, and consequences of, climate change; phthalate exposures in relation to neurodevelopmental outcomes; and the disproportionate burden of environmental chemical and pollutant exposures in communities of color or low income, indigenous peoples, or immigrants in relation to health disparities in neurodevelopmental disorders.