National Consortium on Alcohol and Neurodevelopment in Adolescence: Admin

项目总结 酒精使用和酒精相关伤害的风险在青春期和青壮年(即12岁- 25)，这也是人脑发育的关键时期。响应RFA-AA-17-004，本申请 建议国家酒精和神经发展联盟的管理资源(AR)在 青少年第二阶段(NCANDA-2)，位于加州大学圣地亚哥分校。财团的主要目标是 确定在青春期和青春期大量饮酒的预测因素和影响 具有人口统计学代表性的青少年样本。该联盟旨在协同不同的 每一地点调查人员的科学专长和研究经验。该财团反映了七个 应用程序：NCANDA-管理资源(UCSD)和NCANDA-数据分析资源(SRI)，以及 五个跨国研究项目站点，位于俄勒冈州健康科学杜克大学(Duke) OHSU大学(OHSU)、匹兹堡大学(PITT)、SRI国际(SRI)和加州大学圣地亚哥分校(UCSD)。 在五个地点招募的年龄在12岁到21岁之间的高风险增强型社区样本为831人 完成了一次基线评估和三次年度纵向跟踪评估 设计。NCANDA-2将继续跟随这一队列，直到典型的终生饮酒高峰年龄，使用 多模式神经成像、认知测试、行为访谈、生物样本收集和技术- 加强对自然环境的评估。对酒精后果的审查将集中在 在青春期活跃发育的大脑区域的结构和功能成熟，参与了 自我调节和奖赏反应，似乎容易受到酒精的神经毒性影响。五个目标 RFA中规定的将进行系统测试，重点是青少年药物使用和 神经成熟轨迹。每个研究项目站点与另一个站点协作1-2个额外的 目标。加州大学圣迭戈分校、俄亥俄州立大学和杜克大学正在对酗酒者进行为期4周的监测，检查他们的大脑恢复情况 禁欲。皮特和SRI合作研究酗酒、睡眠特征和大脑之间的关系 发展。我们正在研究大量饮酒对抑制功能障碍的影响，以及 在抗眼跳过程中，使用纵向功能磁共振连通性分析，这可以调节认知表现 (PITT，Duke)和Stroop匹配到样本(SRI和UCSD)任务。具有额外的特定于开发的 由这次更新提供的纵向数据，我们将确定酒精暴露对 青春期人脑的发育轨迹，并确定先前存在的心理生物学 可能使青少年或年轻人患酒精使用障碍或其他疾病的风险增加的脆弱性 不利的人生结局。

PROJECT SUMMARY Alcohol use and risk for alcohol-related harm is prevalent in adolescence and young adulthood (i.e., age 12- 25), and this is also a critical time in human brain development. In response to RFA-AA-17-004, this application proposes the Administrative Resource (AR) of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2), located at UC San Diego. The overarching consortium goals are to determine the predictors and effects of heavy alcohol use in adolescence and young adulthood in a demographically representative sample of adolescents. This consortium was designed to synergize the diverse scientific expertise and research experience of the investigators at each site. This consortium reflects seven applications: NCANDA - Administrative Resource (UCSD) and NCANDA - Data Analysis Resource (SRI), and five cross-national Research Project Sites, located at Duke University (Duke), Oregon Health Science University (OHSU), University of Pittsburgh (Pitt), SRI International (SRI), and UC San Diego (UCSD). Recruited at ages 12 through 21 across the five sites, a high-risk enhanced community sample of 831 subjects completed a baseline assessment and three annual follow-up assessments in an accelerated longitudinal design. NCANDA-2 will continue to follow this cohort through the typical age of lifetime peak drinking, using multimodal neuroimaging, cognitive testing, behavioral interviews, biospecimen collection, and technology- enhanced assessment in the natural environment. Examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence, are involved in self-regulation and reward response, and appear vulnerable to neurotoxic effects of alcohol. Five aims specified in the RFA will be systematically tested with a focus on adolescent substance use and neuromaturational trajectories. Each Research Project Site collaborates with another site on 1-2 additional aims. UCSD, OHSU, and Duke are examining brain recovery in heavy drinkers over 4 weeks of monitored abstinence. Pitt and SRI collaborate to study relations between heavy drinking, sleep characteristics, and brain development. We are examining the influence of heavy drinking on inhibitory dysfunction and the extent to which this mediates cognitive performance, using longitudinal fMRI connectivity analysis during anti-saccade (Pitt, Duke) and Stroop match-to-sample (SRI and UCSD) tasks. With the additional development-specific longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent or young adult at elevated risk for an alcohol use disorder or other adverse life outcome.