Harmonizing Cognitive Assessments in Irish, English, and American Longitudinal Studies: Supporting Cross-National Research on the Epidemiology of Dementia

项目摘要 该项目旨在扩大可用于跨国研究的资源， 阿尔茨海默病和阿尔茨海默病相关痴呆（AD/ADRD）。虽然认知障碍和 痴呆症给世界各地的家庭和政府带来了巨大的负担，研究正在进行中。 在许多地方，只有相对较少的协调一致的研究才能进行良好的比较或综合研究， 分析，以利用跨国差异的决定因素和结果的痴呆症。健康和 退休研究（HRS）系列国际老龄化纵向研究在许多方面密切协调， 测量的维度，并致力于公共共享数据，以鼓励研究。统一 认知评估协议（HCAP）的开发提供了一个共同的坚实基础，以实现 在该网络内对损伤和痴呆进行更可比的评估， 在外面学习。 HCAP已经在HRS的3，400多名美国参与者和1，200多名 英国老龄化纵向研究（艾尔莎）的参与者。该项目将增加1，400名 来自爱尔兰老龄化纵向研究（TILDA）的参与者在爱尔兰共和国和1000 来自北方爱尔兰队列老龄化纵向研究（NICOLA）的参与者。所有四项研究都有 基因组数据来支持研究。作为独立队列，这些研究将支持 痴呆症和认知障碍在每个国家的患病率，并创造未来的机会， 纵向随访以测量发病率。结合母研究的较大样本 它们可以用来在更大的范围内创建协调的认知状态测量， 全样本的流行病学研究。 北方爱尔兰和爱尔兰共和国有许多共同的遗传和环境因素， 经历了政治暴力带来的独特压力。我们将研究它对DNA甲基化和 认知障碍和痴呆症。爱尔兰的研究与临床护理密切相关， 对HCAP协议进行有价值的临床诊断验证。爱尔兰研究带来了 心血管健康的独特有价值的措施，可以研究其与痴呆症的关联， 包括作为福尔斯的关键危险因素的神经心血管不稳定。他们也有视网膜成像， 可以检测脑微血管疾病，并进行详细的营养评估， 在美国的人口代表性研究。

PROJECT SUMMARY This project aims to expand the resources available for cross-national research on the epidemiology of Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD). While cognitive impairment and dementia impose enormous burdens on families and governments around the world, and research is ongoing in many places, there are relatively few well-harmonized studies that allow good comparative or integrative analysis to exploit cross-national differences in determinants and outcomes of dementia. The Health and Retirement Study (HRS) family of international longitudinal studies of aging are closely harmonized on many dimensions of measurement and committed to public sharing of data to encourage research. The Harmonized Cognitive Assessment Protocol (HCAP) was developed to provide a common strong foundation to achieve more comparable assessments of impairment and dementia within this network and better harmonization to studies outside it. The HCAP has already been conducted with over 3,400 US participants in the HRS and with over 1,200 participants in the English Longitudinal Study of Ageing (ELSA). This project will add an additional 1,400 participants from the Irish Longitudinal Study of Ageing (TILDA) in the Republic of Ireland and 1,000 participants from the Northern Ireland Cohort Longitudinal Study of Ageing (NICOLA). All four studies have genomic data available to support research. As stand-alone cohorts these studies will support estimates of the prevalence of dementia and cognitive impairment in each nation and create the opportunity for future longitudinal follow-up to measure incidence rates. In conjunction with the larger samples of the parent studies they can be used to create harmonized measures of cognitive status on an even larger scale to support epidemiologic research on the full samples. Northern Ireland and the Republic share many genetic and environmental factors but the North experienced unique stress due to political violence. We will study its impact on DNA methylation and on rates of cognitive impairment and dementia. With their close association to clinical care, the Irish studies will undertake a valuable validation of the HCAP protocol against clinical diagnoses. The Irish studies bring uniquely valuable measures of cardiovascular health that can be studied for its association with dementia, including neurocardiovascular instability that is a key risk factor for falls. They also have retinal imaging that can detect cerebral microvascular disease, and detailed nutritional assessments not generally available in population-representative studies in the US.