Ambulatory Methods for Measuring Cognitive Change

项目摘要 需要对认知变化进行准确和灵敏的测量，以推进 认识规范认知老化，提高对微妙认知的检测 神经退行性疾病临床前阶段的变化，如阿尔茨海默氏症。 响应RFA-AG-18-012，我们建议开发用于移动监控的基础设施 认知变革(M2C2)将为研究社区提供开放、灵活和 使科学进步有赖于灵敏和准确的可用工具 对认知变化的测量。我们将通过完成以下工作来建设这个基础设施 遵循目标。首先，我们将建立快速迭代试验和测试开发程序 加快我们构建、部署、评估和优化候选移动设备的能力 满足心理测量、可访问性和参与度基准的认知测试(目标1： 迭代设计和试验)。第二，评估信度、结构效度和纵向效度 移动认知测试程序(目标2：信度和效度)在不同种族人群中的有效性 概率样本。第三，我们将心理测量结果复制到一个独立的、全国性的 以代表性概率为基础的样本，并创建具有全国代表性的规范(目标3： 复制)。第四，我们将测试我们的管道和程序，以纳入新的 通过评估纳入的新措施，将措施纳入移动评估基础设施 由我们直接研究团队以外的研究人员提名(目标4：扩展)。

Project Summary Accurate and sensitive measurement of cognitive change is required to advance the understanding of normative cognitive aging and improve the detection of the subtle cognitive changes during preclinical stages of neurodegenerative diseases, such as Alzheimer's. In response to RFA-AG-18-012, we propose to develop infrastructure for the Mobile Monitoring of Cognitive Change (M2C2) that will provide the research community with open, flexible, and usable tools to enable scientific progress that depends on the sensitive and accurate measurement of cognitive change. We will build this infrastructure by accomplishing the following aims. First, we will establish rapid iterative piloting and test development procedures that accelerate our capacity to prototype, deploy, evaluate, and optimize candidate mobile cognitive tests to meet psychometric, accessibility, and engagement benchmarks (Aim 1: Iterative Design & Piloting). Second, evaluate reliability, construct validity, and longitudinal validity of mobile cognitive testing procedures (Aim 2: Reliability & Validity) in a racially diverse probability sample. Third, we replicate psychometric results in an independent, nationally representative probability based sample, and create nationally representative norms (Aim 3: Replication). And fourth, we will test our pipeline and procedures for incorporating new measures into the mobile assessment infrastructure by evaluating novel measures for inclusion that are nominated by investigators outside of our immediate research team (Aim 4: Extension).