Human Subjects and Assessment Core

摘要 密歇根大学人类受试者和评估核心（HSAC）提供基础设施， UM OAIC研究人员进行临床和转化研究的关键资源。HSAC密切关注 与UM OAIC的目标一致，即将实验室，临床和结果研究与临床实践相结合。通过 HSAC将与拉丁美洲和加勒比地区、区域经济委员会、区域经济委员会和其他三个资源中心密切合作，协助非洲信息和通信组织- 资助的试点项目和其他外部资助的项目（EP）与OAIC的中心研究主题有关。 HSAC的重要优先事项将是支持年轻教师对老龄化研究的新认识， 将研究发现转化为人类研究，并支持有希望的高影响力临床试验， 减少残疾和改善老年人的身体/认知功能。HSAC的具体目标 是：1.促进研究者访问人类受试者和相关数据集 2.与OAIC中心主题有关;就下列问题向国际移民组织研究人员提供培训和咨询： 与实验设计（授予前和授予后）、人类受试者的招募/保留、 动物到人类研究，技术比较国家数据库; 3.扩大和促进对以下方面的研究： 影响易感因素、代谢/炎症介质的种族、民族和文化影响，以及 老年人的功能和健康结果; 4.加强社区参与老龄化研究， 促进OAIC研究在当地社区和学术界的传播。

Abstract The University of Michigan Human Subjects and Assessment Core (HSAC) provides the infrastructure and resources critical to UM OAIC investigators performing clinical and translational research. The HSAC is closely aligned with the UM OAIC’s goal of integrating bench, clinical and outcome research with clinical practice. By working closely with the LAC, REC, PESC and the three other Resource Cores, the HSAC will assist OAIC- funded pilots and other externally funded projects (EPs) related to the central research theme of the OAIC. Important priorities for the HSAC will be to support junior faculty new to aging research, the translation of basic research discoveries into human studies, and to support high impact clinical trials that have the promise of reducing disability and improving physical/cognitive function in older adults. The Specific Aims of the HSAC are: 1. To facilitate access to human subjects and related data sets by investigators implementing research related to the central OAIC theme; 2. To provide training and consultation to OAIC researchers on issues related to experimental design (pre- and post-award), recruitment/retention of human subjects, translation from animal into human studies, techniques to compare national databases; 3. To expand and promote research on racial, ethnic, and cultural influences affecting the predisposing factors, metabolic/inflammatory mediators, and functional and health outcomes in older adults; 4. To enhance community engagement in aging research and facilitate the dissemination of OAIC research in the local community as well as the academic community.