Quantitative Behavioral Assessment & Rehabilitation (QBAR)

量化行为评估和康复核心(QBAR)继续建立在四个实验室的基础上 在健康专业学院内提供行为功能的最新测量(例如， 3-D运动学、动力学和肌电图学)和康复干预(运动，强迫诱导 中风后偏瘫患者的运动和强化任务导向的上肢训练)。在当前 实践中，临床医生可用的测量和干预框架在理论上是不够的， 确定卒中后患者的相关缺陷并制定有效的干预措施是不切实际的。我们 相信康复必须朝着这样一种模式发展：a)一个人的运动控制系统的健康 可以被分析，b)可以识别特定的缺陷，c)可以使用特定的治疗来针对这些缺陷， 以及d)量化措施可以评估治疗前和治疗后的状态。这个核心支撑着 研究人员通过五个具体目标制定测量和干预框架 包括：1)定量行为评估，使研究人员能够研究大脑的测量 可塑性和行为可用于指导和个体化康复和/或恢复性治疗。堆芯 这一角色的服务包括：运动捕捉和肌电图仪，用于精确测量运动和肌肉 活动性.用氧气消耗测量的能量学.测量活动性的基于加速度计的装置 如行走和偏瘫手臂的使用；测量单个关节的力量和力量的神经肌肉测量； 临床测量；以及动物行为分析设备。2)康复，使Cobre调查人员能够 研究卒中后可塑性的经验依赖性，通过标准化经验来优化 使用当前最先进的方法和/或正在开发的恢复性疗法的治疗效果 新颖的工具或方法。这一角色的核心服务包括：运动康复；上肢康复； 与动物模型康复相适应的动物中风模型。3)基于理论的结果的发展 衡量(行为“生物标记物”)和形成地方、国家的大量量化行为数据 和国际数据共享。4)对所有Cobre调查人员进行多学科方案指导。5) 推动Qbar Core成为中风康复研究的领先地方/国家/国际资源。 科布雷基金将帮助支持训练有素的技术人员进行关键研究和培训 Qbar实验室内的职能，以及具有专业专业知识的专业人员 康复科学、运动和能量学方面的资源导师，以及独特动物模型的使用。Qbar 将为所有Cobre附属调查人员提供指导和咨询，特别是那些没有 在行为/功能测量和康复方面的专业知识。总体目标是利用Qbar和 被认为是来自南卡罗来纳州和其他地方的中风康复研究人员的首选之地。

The Quantitative Behavioral Assessment & Rehabilitation Core (QBAR) continues to build on four laboratories within the College of Health Professions to provide state-of-the-art measurements of behavioral function (e.g., 3-D kinematics, kinetics and electromyography) and rehabilitation interventions (locomotor, constraint-induced movement and intensive task-oriented upper extremity training) in hemiparetic post-stroke patients. In current practice, the measurement and intervention framework available to clinicians is theoretically insufficient and impractical to determine relevant deficits of a post-stroke patient and prescribe efficacious interventions. We believe that rehabilitation must move toward a model where: a) the health of a person’s motor control system can be assayed, b) specific deficits can be identified, c) specific treatments can be used to target the deficits, and d) quantitative measures can provide assessment of pre- and post-treatment states. This core supports investigators in their development of measurement and intervention frameworks via five specific aims that encompass: 1) Quantitative Behavioral Assessment, enabling investigators to study how measures of brain plasticity and behavior can be used to guide and individualize rehabilitation and/or restorative therapies. Core services in this role include: motion capture and electromyography for precise measures of motion and muscle activity; energetics as measured by oxygen consumption; accelerometer-based devices for measuring activities such as walking and hemiparetic arm use; neuromuscular measures of strength and power of individual joints; clinical measures; and animal behavioral assay equipment. 2) Rehabilitation, enabling COBRE investigators to study the experience-dependent nature of post-stroke plasticity by standardizing experience to optimize the treatment effects of restorative therapies through the use of current state-of-the-art methods and/or developing novel tools or methods. Core services in this role include: locomotor rehabilitation; upper extremity rehabilitation; and animal model rehabilitation appropriate to animal stroke models. 3) Development of theory-based outcome measures (behavioral “biomarkers”) and formation of large quantitative behavioral data sets for local, national and international data sharing. 4) Multidisciplinary programmatic mentoring of all COBRE investigators. 5) Promotion of the QBAR Core as a leading local/national/international resource for stroke recovery research. COBRE funds will help support highly trained technical personnel to perform critical research and training functions within the QBAR labs, as well as professional personnel with specialized expertise to serve as Resource Mentors in rehabilitation science, exercise and energetics, and use of unique animal models. QBAR will provide mentoring and consultation to all COBRE-affiliated investigators, especially those without primary expertise in measurement of behavior/function and rehabilitation. The overall goal is for QBAR to be utilized and recognized as the “go-to” place for stroke rehabilitation researchers from across South Carolina and elsewhere.