Core 2: Biostatistics Shared Resource Core

项目摘要：生物统计和生物信息学共享资源核心 在这一应用中，我们建议加强我们现有的Meharry医学院/Vanderbilt-Ingram的作用 癌症中心/田纳西州立大学癌症伙伴关系(MVTCP)生物统计学和生物信息学 共享资源核心(BBSRC)。BBSRC将支持拟议的两个全面项目和一个试点项目； 为每个特定目标/子目标提供详细和具体的生物统计和生物信息分析计划 在每个项目中。计算每个主要实验的样本量，以提供高功率检测 临床上或生物学上相关的影响。对于具有高维数据分析的项目，描述的方法 将应用研究策略来评估数据质量，然后才进行统计分析 用于解决质量问题的前处理。所有MVTCP研究都需要BBSRC的支持，生物统计学家 以及来自这个核心的生物信息学家分配给每个项目。BBSRC人员已经并将继续工作 与项目负责人密切合作，确保生物统计学和生物信息学共享资源核心 为MVTCP提供最先进的统计/生物信息学支持。

PROJECT SUMMARY: BIOSTATISTICS AND BIOINFORMATICS SHARED RESOURCE CORE In this application, we propose to intensify the role of our existing Meharry Medical College/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) Biostatistics and Bioinformatics Shared Resource Core (BBSRC). The BBSRC will support the proposed two full projects and one pilot project; detailed and specific biostatistical and bioinformatic analysis plans are provided for each specific aim/sub-aim within each project. Sample size for each primary experiment is computed to provide high power to detect clinically or biologically relevant effects. For projects with high-dimensional data analyses, the methods described in the Research Strategy will be applied to assess data quality and then perform statistical analysis only after preprocessing to address quality issues. BBSRC support is required for all MVTCP studies, with biostatisticians and bioinformaticians from this core assigned to each project. BBSRC personnel have worked and will continue to work closely with project leaders to ensure the Biostatistics and Bioinformatics Shared Resource Core provides state-of-the-art statistical/bioinformatic support to the MVTCP.