Training in Cellular, Molecular and Biomedical Studies (CMBS)

摘要 在细胞，分子和生物医学研究（CMBS）的综合计划是一个伞计划， 为学生提供了一个独特的机会，获得生物医学科学各个方面的个性化培训， 包括基础细胞和分子生物学，微生物学，结构生物学，生物物理学，遗传学，免疫学， 神经生物学，系统和计算生物学，以及转化生物医学疾病相关的研究。 该计划的基本原理是为研究生提供一个全面的基础， 生物化学、遗传学、细胞和分子生物学的基础知识。目的是 扩大和统一的研究生课程，CMBS计划已扩大到不仅包括一个 伞形轨道，但也包括结构生物学/分子生物物理学、细胞生物学/干细胞生物学， 微生物学和免疫学，病理生物学和疾病机制，癌症生物学和系统生物学。 所有的学生在这些轨道采取相同的'核心课程'，然后选择选修课程，具体到 跟踪. CMBS项目的一个独特之处在于，学生可以选择留在“保护伞”轨道上， 从而使他们能够选择适合自己兴趣的课程。对于核心课程， 学员将学习生物化学，细胞和分子生物学，分子遗传学和统计学等课程。他们 将参加负责任地进行研究的课程，以及严格性和可重复性的培训。他们将不得不 有很多机会展示他们的研究，并将在毕业前提交第一作者论文。学生 在这个培训计划将学习评估和分析生物医学文献批判性和识别重要的 生物医学研究问题。他们还将评估重要问题，并确定研究是否 问题进行了严格的处理，制定了一个独立的研究计划，严格和可重复的 实验设计，定量方法和数据解释，并确定负责任的行为规则 研究。作为培训的一部分，他们将学习独立，负责和严格地进行研究 并单独和作为研究团队的一部分开展工作。在完成培训计划后， 他们将能够向更广泛的受众介绍研究，无论是口头还是书面报告，并评估 毕业后可从事生物医学研究的可能职业。CMBS计划接待一名学生 研究研讨会系列和两年一度的学生教师务虚会。大多数学生在5-6年内毕业。我们计划 资助八名学生在研究生学习的头两年学习两年。CMBS计划仍然 哥伦比亚大学医学中心的首要细胞和分子生物学研究生课程， 培训补助金的发放对于该计划的持续成功至关重要。

ABSTRACT The Integrated Program in Cellular, Molecular and Biomedical Studies (CMBS) is an umbrella program that presents students with a unique opportunity to obtain individualized training in all aspects of biomedical sciences, including basic cell and molecular biology, microbiology, structural biology, biophysics, genetics, immunology, neurobiology, systems and computational biology, as well as translational biomedical disease-related research. The underlying rationale for this program was to provide graduate students with a thorough grounding in the basics of biochemistry, genetics, cell and molecular biology through a series of ‘core courses.’ With the aim of expanding and unifying the graduate programs, the CMBS program has been expanded to include not only an umbrella track, but also tracks in Structural Biology/Molecular Biophysics, Cell Biology/Stem Cell Biology, Microbiology and Immunology, Pathobiology and Mechanisms of Disease, Cancer Biology and Systems Biology. All the students in these tracks take the same ‘core courses’ and then choose elective courses specific to the tracks. One of the unique aspects of the CMBS program is that students can elect to stay in the “umbrella” track, thereby allowing them to choose their own program of courses that fit their interests. For the core courses, trainees will take courses in biochemistry, cell and molecular biology, molecular genetics and statistics. They will take courses in responsible conduct of research, and training in rigor and reproducibility. They will have many opportunities to present their research and will submit a first author paper before they graduate. Students in this training program will learn to evaluate and analyze biomedical literature critically and identify important biomedical research questions. They will also assess the significant questions and to determine if the research questions were approached rigorously, develop an independent research plan with rigorous and reproducible experimental design, quantitative approaches and data interpretation and identify rules of responsible conduct of research. As part of their training they will learn to perform research independently, responsibly and rigorously and conduct work both individually and as part of a research team. Upon completion of the training program, they will be able to present research to a wider audience, both in oral and written presentations and evaluate the possible careers in biomedical research that are available upon graduation. The CMBS Program hosts a student research seminar series and a biennial student faculty retreat. Most students graduated in 5-6 years. We plan to support eight students for two years during their first two years of graduate study. The CMBS Program remains the premier cellular and molecular biology graduate program at Columbia University Medical Center and support from this Training Grant is crucial for the continued success of this program.