PRIDE Summer Institute in Cardiovascular Disease Comorbidities, Genetics and Epidemiology (CVD-CGE)

项目摘要。 华盛顿大学回应RFA-HL-19-002的Pride申请建议在我们的基础上 当前成功的夏季学院(SI)计划，并根据我们在以下方面的经验显著增强该计划 以及从我们的SIPID/PROID项目中吸取的经验教训。我们增强计划的首要目标是 提供创造性和高度相关的教育活动，主要侧重于研究经验和 加强生物医学研究队伍多样性的辅导活动。我们将实现这一目标 通过招聘传统上在生物医学研究劳动力中代表性不足的初级教员， 包括：a)来自种族/族裔群体的个人在与健康有关的领域被证明在全国范围内任职人数不足 科学；B)肢体残疾人士；C)弱势背景人士；及(D) 女人。我们的Wu SIPID/Pride项目(9个队列，12年内有47名学员)非常 成功：我们的学员在进入Wu SIPID/PROID之前没有获得任何NIH“R”资助 计划，但计划结束后，他们获得了9项R资助，其中包括7名R01的S(所有资助的总数 在培训期间/培训后增加了73%)。在SIPID/PROID期间/之后出版的出版物总数为 有784篇同行评议的文章，比计划前增加了443%，令人印象深刻。通过 在下面列出的建议活动中，我们的学员将接受培训，以制定独立的研究计划 与心、肺、血液和睡眠(HLBS)障碍相关的区域。根据来自当前和 对于以前的实习生、教师和导师，我们提出了一个显著增强的自豪感计划。亮点： Wu Pride续签申请包括：a)对高度相关的心血管疾病合并症和 流行病学说教讲座。目前对遗传流行病学和生物信息学的深入关注将 继续在网上提供教育材料(电子学习)；b)继续并更加重视 对学员的研究项目进行有效的指导和日常集思广益；c)强烈的写作技巧 发展，特别注重撰写科学手稿；d)发展竞争性赠款 申请新的“小型研究项目(SRP)”项目；E)从前4名中各招募8名学员 年(从3年增加)；F)2周长的第一次和第二次SI(从3周减少)；G)一年 指导，包括为期3天的年中会议和在贝塞斯达举行的为期3天的年会；H)为期2周的第2次 SI，SI小组之间有3天的重叠，以促进网络和同行指导；i)为期2年的跟踪 每个SI队列记录与HLBS障碍相关的领域的进展，赠款和手稿写作 学术进步(不变)。初级教员，过渡博士后研究员和科学家 处于事业早期并已宣布专注于HLBS障碍研究的残疾人士将 被招募。该计划的有效性将根据受训者在确保独立方面的成功程度进行评估 赠款支持、科学出版物和学术推广。

Project Summary. PRIDE application from Washington University in response to RFA-HL-19-002 proposes to build upon our current successful Summer Institute (SI) program and to significantly enhance it based on our experiences with and lessons learned from our SIPID/PRIDE programs. The overarching goal of our enhanced program is to provide creative and highly relevant educational activities with primary focus on research experiences and mentoring activities for enhancing diversity of the biomedical research workforce. We will accomplish this goal by recruiting junior faculty who are traditionally underrepresented in the biomedical research workforce, including: A) individuals from racial/ethnic groups shown to be nationally underrepresented in health-related sciences; B) individuals with physical disabilities; C) individuals from disadvantaged backgrounds; and (D) Women. Our WU SIPID/PRIDE programs (9 cohorts, 47 mentees over 12 years) have been extremely successful: our mentees had not received any NIH “R” grants before they entered the WU SIPID/PRIDE program, but after the program they received 9 “R” grants including 7 R01's (total number of all grants increased by 73% during/after training). The total number of publications during/after SIPID/PRIDE has been 784 peer-reviewed articles, an impressive 443% increase compared to before the program. Through the proposed activities listed below, our mentees will be trained to develop independent research programs in areas relevant to Heart, Lung, Blood, and Sleep (HLBS) disorders. Based on feedback from current and former trainees, faculty and mentors, we propose a significantly enhanced PRIDE program. Highlights of the WU PRIDE renewal application include: A) a new focus on highly-relevant CVD comorbidities and epidemiology didactic lectures. Current in-depth focus on Genetic Epidemiology and Bioinformatics will continue, with educational material available on web (e-learning); B) continued and increased emphasis on effective mentoring and daily brainstorming of mentees' research projects; C) intense writing skills development, with particular focus on writing scientific manuscripts; D) development of competitive grant applications for the NEW “Small Research Project (SRP)” program; E) recruiting 8 Mentees each of the first 4 years (increased from 3 years); F) 2-week long 1st and 2nd SI (decreased from 3 weeks); G) year-long mentoring that includes a 3-day mid-year meeting and 3-day annual meeting in Bethesda; H) 2-week long 2nd SI, with 3-day overlap between SI groups to facilitate networking and peer-mentoring; I) 2-year follow-up of each SI cohort to document progress in areas relevant to HLBS disorders, grant and manuscript writing and academic advancement (unchanged). Junior faculty, transitioning post-doctoral fellows and scientists with disabilities who are in early stages of their careers and with a declared research focus in HLBS disorders will be recruited. Effectiveness of the program will be assessed by mentees' success in securing independent grant support, scientific publications and academic promotions.