Azheimer's Disease Risk and Ethnic Factors: the Case of Arab Americans- Administrative Supplement for Increased Costs

增加费用补充--阿尔茨海默病风险和种族因素：阿拉伯国家的情况 美国人 申请NIA行政补充是为了解决史无前例的成本 新冠肺炎强制面对面数据收集后延迟两年产生的涨幅 关机。我们注意到，阿尔茨海默氏症项目的原始供资范围没有变化 疾病风险和种族因素：阿拉伯裔美国人的案例(R01AG057510)。尽管耽搁了很久，但没有 干预性研究降低了拟议研究的重要性或独特性，这将显著 通过以下途径增进我们对阿尔茨海默病(AD)和移民健康方面的种族/民族差异的了解 它的重点是代表严重不足的人口。该项目还将提供目前无法获得的阿拉伯语 有助于研究人员和临床医生评估轻度疾病的仪器和标准数据 阿拉伯裔美国人中的认知障碍(MCI)和阿尔茨海默病。具体目标是：1)表征认知和 底特律大都市阿拉伯裔美国人的AD风险；2)决定移民因素对认知的贡献 和老年阿拉伯裔美国人的AD风险；3)确定对以下方面影响最大的社交网络 认知与AD风险。提交本附录的目的是为了保持原批准的 研究的目的、目的和预期的总体影响。两年的COVID延迟打击了这一开创性的 学习特别努力，在经济上一直是毁灭性的。让阿拉伯裔美国人在AD研究中可见一斑 它概括了NIA关于AD差异的战略方向，因为它将提供关于MCI和AD的第一批数据 在具有地区代表性的阿拉伯裔美国人样本中的流行率。阿拉伯裔美国人比例不成比例 在研究中代表性不足，但对促进与健康差距有关的知识很有价值。此外， 计划样本确定和数据收集是本项目原有范围形成的两个基础 单独资助的R01研究(见图1)；该研究的完成取决于这一额外的资金申请。 项目可交付成果将包括目前尚不存在的关键评估工具，以及对 广告差异和移民健康，以及有效管理这一日益增长和高成本的关键信息 疾病发生在不同的老年人中。

Increased Costs Supplement- Alzheimer's Disease Risk and Ethnic Factors: The Case of Arab Americans This application for a NIA Administrative Supplement is requested to address the unprecedented cost increases arising from the two-year delay that followed the COVID-19 mandatory face-to-face data collection shutdown. We note that there has been no change in the original funded scope of the project Alzheimer's Disease Risk and Ethnic Factors: The Case of Arab Americans (R01AG057510). Despite the delay, no intervening research has reduced the importance or uniqueness of the proposed study, which will significantly advance our knowledge of racial/ethnic disparities in Alzheimer's disease (AD) and immigrant health through its focus on a severely underrepresented population. This project will also provide currently unavailable Arabic instruments and normative data that will assist both researchers and clinicians in the assessment of Mild Cognitive Impairment (MCI) and AD in Arab Americans. The specific aims are to: 1) Characterize cognition and AD risk among Arab Americans in metro-Detroit; 2) Determine the contribution of immigrant factors to cognition and AD risk among older Arab Americans; 3) Identify aspects of social networks that have greatest effects on cognition and AD risk. This supplement is submitted to preserve the integrity of the originally approved objectives, purpose and expected overall impact of the study. The two-year COVID delay hit this pioneering study especially hard and has been financially devastating. Making Arab Americans visible in AD research epitomizes NIA's strategic directions related to AD disparities, as it will provide the first data on MCI and AD prevalence in a regionally representative sample of Arab Americans. Arab Americans are disproportionately underrepresented in research yet valuable to advancing knowledge related to health disparities. Further, the planned sample identification and data collection of this project's original scope form the foundation of two separately funded R01 studies (see Fig.1); completion of which hinges on this additional funding request. Project deliverables will include critical assessment tools that do not currently exist, refined understanding of AD disparities and immigrant health, and key information to effectively manage this growing and high-cost disease in diverse older adults.