Heterologous expression of cyanobacterial compounds of analytical and therapeutic value

该项目小组先前已经发现了蓝藻和藻类产生毒素的遗传基础。该项目旨在确定这些微生物中参与生物碱和环肽毒素生产的独特生物合成酶的生化途径。通过大基因克隆策略的发展，毒素将在稳定、可持续和安全的发酵系统中生产。这些化合物对于全球供水中毒素检测方法的标准化以及评估其在人类和其他动物中的生物活性至关重要。研究生和行业合作伙伴也将接受培训，以应用这些新的生物技术生产其他药物样分子。

The project team has previously discovered the genetic basis for toxin production in cyanobacteria and algae. This project aims to define the biochemical pathways of the unique biosynthetic enzymes involved in alkaloid and cyclic peptide toxin production in these microorganisms. Via the development of large-gene cloning strategies, the toxins will be produced in a stable, sustainable and secure fermentation system. These compounds will be critical for standardising toxin detection methods in water supplies globally and for assessing their bioactivities in humans and other animals. Research students and the industry partner will also be trained to apply these novel biotechnologies for the production of other drug-like molecules.