Claude D. Pepper Older Americans Independence Centers (OAICs)(P30)

摘要 在这份竞争性续签申请中，密歇根大学克劳德·D·佩珀老年美国人 独立中心(UM胡椒中心)成立于，旨在提供科学的领导和 老龄化研究的创新，以解决以代谢和炎症为目标的中心假设 作为老年病情和预后关键中介的因素改善了老年人的身体和认知功能 上了年纪的人。 密歇根州立大学胡椒中心的首要目标是创造、加强和保持一个有凝聚力的知识分子， 技术和行政环境，以最大限度地利用老年学研究，促进健康和 老年人的功能独立性。密歇根大学胡椒中心将在五个目标中追求其目标。目标1) 支持针对中心重点的研究，以提高对代谢因素和 炎症决定了与活动能力和功能状态相关的关键健康结果。目标2)支持 代谢因子和炎症与年龄相关性疾病相互作用的翻译研究 合并症，以改善与活动能力和功能状态相关的健康结果。为了实现这一目标，UM 胡椒中心将与包括密歇根临床与健康研究所在内的其他UM项目密切合作 密歇根大学临床与翻译科学奖(CTSA)的发源地--MICHR。目标3) 提供支持和协助调查员发起的与UM Pepper相关的项目的资源核心 中心的研究重点。目标4)通过其研究教育核心(REC)，加强UM 为未来老年医学和老龄领域的学术带头人提供培训环境，这些带头人可以开展与以下方面的研究 UM胡椒中心的研究重点。目标5)通过其试点和探索性研究核心(PESC)， 吸引密歇根大学教职员工开发与密歇根大学胡椒中心研究重点相关的新研究项目。 UM胡椒中心有一个完善的领导和管理结构，一个REC，一个 PESC和四个RCS：人类受试者和评估核心(HSAC)；生物力学核心(BC)； 设计、数据和生物统计核心(DDBC)；老年啮齿动物核心设施(CFAR)。区域经济共同体 特点有三个核心要素：1)竞争性计划，每年挑选2名有前途的UM初级教员 进行与UM胡椒中心研究相关的研究，并保证50%的研究工作投入 发展；2)为从事此类研究的初级教员制定国家认可的研究培训计划； 以及3)导师计划，增加初级教职员工与 或更多UM高级调查员。PESC将通过利用OAIC每年资助5个或更多的试点项目 利用多个其他UM机构资源提供资金。区域资源中心将支持多个外部资金项目， 胡椒中心试点助学金和REC初级教员，并继续开发和测试新方法 用于胡椒中心的研究。

Abstract In this competitive renewal application, the University of Michigan Claude D. Pepper Older Americans Independence Center (UM Pepper Center), established in 1989, seeks to provide scientific leadership and innovation for aging research to address the central hypothesis that targeting metabolic and inflammatory factors as critical mediators of geriatric conditions and outcomes improves physical and cognitive functions of older adults. The overarching goal of the UM Pepper Center is to create, enhance and maintain a cohesive intellectual, technological, and administrative environment to maximize geriatrics research that will promote health and functional independence in older adults. The UM Pepper Center will pursue its objectives in five Aims. Aim 1) To support research that addresses the Center’s focus to improve understanding of how metabolic factors and inflammation determine key health outcomes related to mobility and functional status. Aim 2) To support translational research on the interaction of metabolic factors and inflammation with age-related diseases and comorbidities to improve health outcomes related to mobility and functional status. To achieve the aim, the UM Pepper Center will work closely with other UM programs including the Michigan Institute for Clinical and Health Research (MICHR), the home of the UM’s Clinical and Translational Science Award (CTSA). Aim 3) To provide Resource Cores that support and assist investigator-initiated projects related to the UM Pepper Center’s research focus. Aim 4) Through its Research Education Core (REC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research related to the UM Pepper Center’s research focus. Aim 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM faculty to develop new research projects related to the UM Pepper Center’s research focus. The UM Pepper Center has in place a well-established leadership and administrative structure, a REC, a PESC, and four RCs: the Human Subjects and Assessment Core (HSAC); the Biomechanics Core (BC); the Design, Data and Biostatistics Core (DDBC); and the Core Facility for Aged Rodents (CFAR). The REC features three central elements: 1) a competitive program to select 2 promising UM junior faculty per year to conduct research relevant to the UM Pepper Center’s research and guarantee 50% effort for research career development; 2) a nationally recognized research training program for junior faculty engaged in such research, and 3) a Mentorship Program that enhances opportunities for junior faculty members to work closely with one or more UM senior investigators. The PESC will fund 5 or more pilot projects per year by leveraging OAIC funding with multiple other UM institutional resources. The RC’s will support multiple externally funded projects, the Pepper Center pilot grants and REC junior faculty, and continue to develop and test new methods to be used in Pepper Center research.