Colorado Nutrition Obesity Research Center

项目摘要--总体构成部分 这是科罗拉多州营养肥胖研究中心的5年竞争续订申请 (NORC)。科罗拉多州NORC的使命是通过促进营养和肥胖的科学发展 跨学科、协作、翻译研究，并通过促进下一代 落基山脉地区的科学家。我们现在是我们运营的第二十五年，科罗拉多州 NORC现在支持118名正式成员、22名附属成员实习生和38名其他附属成员教职员工 科学家和教育家。我们的固定会员每年产生超过5100万美元的直接成本 营养/肥胖研究。我们已获得额外2,000万元的机构资源，以支持 NORC未来5年的研究和教育目标。这项投资建立在4000万美元的基础上 科罗拉多大学及其慈善捐赠者在过去10年中投资建设和 运营安舒茨健康和健康中心，并以编程方式建立营养科学， 肥胖和健康。我们的研究基地从事基础、临床前、临床和社区研究项目， 具有跨学科协作的心态。科罗拉多州北大西洋公约组织的中心主题是 通过改善营养，预防和治疗终生肥胖及其代谢并发症， 生活方式的改变和医疗。我们专门建立和促进跨学科的研究 营养与肥胖：1)早期生活的影响；2)女性的健康和性别差异；3)运动 和新陈代谢；4)新陈代谢的调节；和5)营养和体重管理干预，以更好地 健康。科罗拉多州NORC拥有强大的领导力，保罗·麦克莱恩博士(主任)和丹尼尔·贝森博士 (副主任)，他将协调有效的浓缩方案的活动，这是一个成功的试点 计划，以及三个高生产率的研究核心。他们与校园建立了牢固的合作伙伴关系 为协作研究搭建学科桥梁的领导者。他们引导核心和计划适应 NORC研究基地不断变化的需求。最后，他们招募了一支优秀的团队 核心/项目负责人和内部/外部顾问，确保科罗拉多州NORC完成其 任务。经过25年的运营，科罗拉多号从未像现在这样处于有利地位，能够推进 营养和肥胖症在如此多的战线上，并培养这些领域的下一代领导者。

PROJECT SUMMARY - OVERALL COMPONENT This is an application for a 5 year competitive renewal for the Colorado Nutrition Obesity Research Center (NORC). The MISSION of the Colorado NORC is to advance the science of nutrition and obesity by facilitating interdisciplinary, collaborative, translational research and by fostering the development of the next generation of scientists in the Rocky Mountain region. We are now in our twenty-fifth year of operation, and the Colorado NORC now supports 118 Regular Members, 22 Affiliate Member trainees, and 38 other Affiliate Member faculty scientists and educators. Our regular members generate over $51 million annually in direct costs for nutrition/obesity research. We have secured an additional $20 million in institutional resources to support the NORC's research and educational objectives over the next 5 years. This investment builds upon a $40 million investment from the University of Colorado and its philanthropic donors over the past 10 years to construct and operate the Anschutz Health and Wellness Center and build programmatically in the science of nutrition, obesity, and wellness. Our research base pursues basic, preclinical, clinical, and community research projects, with a mindset for interdisciplinary collaboration. The CENTRAL THEME of the Colorado NORC is the prevention and treatment of obesity and its metabolic complications across the lifespan, through better nutrition, lifestyle modifications, and medical treatments. We specifically build and foster interdisciplinary research on nutrition and obesity in five areas: 1) Early Life Influences; 2) Women's Health and Sex Differences; 3) Exercise and Metabolism; 4) Regulation of Metabolism; and 5) Nutrition and Weight Management Interventions for Better Health. The Colorado NORC has strong leadership with Dr. Paul MacLean (Director) and Dr. Daniel Bessesen (Associate Director), who will coordinate the activities of an impactful enrichment program, a successful pilot program, and three highly productive research cores. They have established strong partnerships with campus leaders that bridge disciplines for collaborative research. They have guided the cores and programs to adapt to the changing needs of the NORC's research base. Finally, they have recruited an outstanding team of core/program leaders and internal/external advisors that will ensure the Colorado NORC accomplishes its mission. After 25 years of operation, the Colorado has never been as well-positioned to advance the science of nutrition and obesity on so many fronts and to foster the next generation of leaders in these fields.