Modulation effects of Baduanjin mind-body exercise on subjective cognitive decline

摘要 主观认知下降(SCD)，即自我报告的记忆或认知问题的知觉，正在接受 越来越多的人关注阿尔茨海默病(AD)的危险因素。由于SCD表现为 在临床损害出现之前，这可能是进行干预的最佳阶段/时间窗口 进展性神经功能丧失前AD和老年性痴呆的预防性治疗 不可逆转的认知障碍。 最近，心身干预已经证明了它们在预防认知衰退方面的潜力。 然而，这些心身疗法包括一系列复杂的实践，每一种都有不同的 特点和重点。因此，它们可能与不同的机制和治疗效果有关。 八段锦(BDJ)是一种创新的简单身心练习，由八个简单的动作组成， 可以在家中通过视频指导轻松练习，从而使其成为更适合老年人的选择 与其他更复杂的运动相比，认知能力有所下降。在之前的一项研究中，我们发现BDJ显著 改善记忆和执行功能，改善海马体的静息状态功能连接 老年人前额叶背外侧皮质、内侧颞区和壳核的灰质体积 成年人。此外，我们还发现，BDJ可以显著改善认知功能，因为 用韦氏记忆量表(WMS)分分数测量，以及更广泛的灰质脑体积 内侧颞叶和壳核的变化。最近的一项初步研究表明，与步行相比， 健康教育方面，BDJ治疗6个月可显著改善MCI患者的认知功能。这些 研究结果为当前的应用提供了坚实的基础。 本研究旨在探讨1)纵向补肾健脑冲剂对认知功能减退的预防作用，2)对认知功能减退的影响。 补阳还五汤对静息状态下大鼠双侧背外侧及海马功能连通性的调节作用 前额叶皮质；3)补肾活血方对SCD AS患者脑形态计量学的调节作用 与对照组相比。我们相信，这项研究将1)显著改善MCI和AD的预防，并 直接受益于这些高度流行的疾病的患者，2)加强我们对 通过身心干预影响认知和健康的神经生物学，以及3)促进我们的 了解SCD、AD和年龄相关性痴呆的病理生理学和发展。

Summary Subjective cognitive decline (SCD), the self-reported perception of memory or cognitive problems, is receiving increasing attention as a risk factor for the development of Alzheimer’s disease (AD). Since SCD manifests before the onset of clinical impairment, it might be the optimal stage/window of time at which to intervene with preventative therapies for AD and age-related dementia before the progressive neurological loss and irreversible cognitive impairment. Recently, mind-body interventions have demonstrated their potential in preventing cognitive decline. Nevertheless, these mind-body therapies encompass a family of complex practices, each with different characteristics and focus. Therefore, they may be associated with different mechanisms and treatment effects. Baduanjin (BDJ) is an innovative and simple mind-body exercise consisting of eight simple movements that can be easily practiced at home with video guidance, thereby making it a more suitable option for older adults with cognitive decline than other more complex exercises. In a previous study, we found that BDJ significantly improved memory and executive function, resting state functional connectivity of the hippocampus and dorsolateral prefrontal cortex, and grey matter volume of the medial temporal area and putamen in older adults. In addition, we found that BDJ could produce significantly greater cognitive function improvement, as measured by the Wechsler Memory Scale (WMS) sub-score, and more extensive grey matter brain volume changes at medial temperal lobe and putamen. A more recent pilot study showed that, compared to walking and health education, six months of BDJ significantly improved cognitive function in patients with MCI. These findings provide a solid foundation for the current application. This proposal aims to investigate 1) the preventative effect of longitudinal BDJ on cognitive decline, 2) the modulation effect of BDJ on resting state functional connectivity of the hippocampus and bilateral dorsolateral prefrontal cortex, and 3) the modulation effect of BDJ on brain morphometry in individuals with SCD as compared to controls. We believe that this study will 1) significantly improve the prevention of MCI and AD and directly benefit patients suffering from these highly prevalent disorders, 2) enhance our understanding of the neurobiology through which mind-body interventions affect cognition and health, and 3) advance our understanding of the pathophysiology and development of SCD, AD, and age-related dementia.