CHEMICAL SCREENING AND OPTIMIZATION FACILITY (CSOF) - CHEMICAL OPTIMIZATION APPROACHES

尤尼斯·肯尼迪·施莱弗国家研究所避孕研究部(CRB) 儿童健康和人类发展部(NICHD)支持研究开发 会扰乱卵子发生、精子发生、正常排卵、精子成熟和/或功能 提供可为男性和/或女性实施的安全有效的避孕药具。这个 化学筛选和优化设施(CSOF)旨在通过识别、优化和进行实现以下目标的小规模分子制剂生产来发挥独特的作用 避孕效果。CSOF根据新避孕方法的开发提供全面的项目管理和支持这些目标的能力，这些方法包括但不限于重组多肽和蛋白质的产生、分析开发、高通量筛选(HTS)、X射线结晶学、计算化学、药物化学和药理学。CSOF确定和优化的化合物将根据非良好制造规范(Non-GMP)进行制备，以进行进一步的临床前评估。CSOF在CRB的药物开发任务中发挥着关键作用。

The Contraception Research Branch (CRB) within the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) supports research to develop compounds that can disrupt oogenesis, spermatogenesis, normal ovulation, sperm maturation and/or function affording safe and effective contraceptives that can be implemented for men and/or women. The Chemical Screening and Optimization Facility (CSOF) is designed to fulfill a unique role by identifying, optimizing, and conducting small scale production of molecular agents that achieve a contraceptive effect. The CSOF provides overall project management and the capabilities to support these objectives pursuant to development of new contraceptive methods: these include, but are not limited to, the generation of recombinant peptides and proteins, assay development, high throughput screening (HTS), x-ray crystallography, computational chemistry, medicinal chemistry, and pharmacology. Compounds identified and optimized by the CSOF will be prepared under non-Good Manufacturing Practices (non-GMP) for further preclinical evaluation. The CSOF plays a critical role in the drug development mission of the CRB.