The UNC Chapel Hill Superfund Research Program (UNC-SRP)

项目描述 摘要：虽然产前暴露于环境金属，如无机砷， 与胎龄减少相关，关于 胎盘的分子驱动力。许多流行病学研究表明， 与接触个别环境金属有关，例如无机砷和铅， 胎龄下降。这些研究通常是单独分析化学品暴露 在混合物中。这种分析方法并没有反映出人类暴露于 可能具有相互作用或协同作用的环境化学品的复杂混合物。 忽视这些综合影响的可能性可能会掩盖这种关联的全部范围 暴露于环境金属和胎龄之间的关系。本项目将研究 生命早期暴露于环境金属与胎龄之间的关系。的 金属将被单独分析以及混合物。随后，为了识别生物 我们将鉴定出这种关联背后的特定miRNAs和蛋白质， 胎盘可能介导金属暴露和胎龄之间的关联。

PROJECT DESCRIPTION Summary: While prenatal exposure to environmental metals, such as inorganic arsenic, is associated with decreased gestational age, there is a fundamental knowledge gap regarding the placental molecular drivers of this association. Numerous epidemiological studies have associated exposure to individual environmental metals, such as inorganic arsenic and lead, with decreased gestational age. Often such studies analyze chemical exposures individually instead of in mixtures. This analytical approach does not reflect the fact that humans are exposed to complex mixtures of environmental chemicals that may have interactive or synergistic effects. Ignoring the possibility of these combined effects may obscure the full extent of the association between exposure to environmental metals and gestational age. This project will examine the association between exposure to environmental metals early in life and gestational age. The metals will be analyzed individually as well as a mixture. Subsequently, to identify biological mechanisms underlying this association, we will identify specific miRNAs and proteins within the placenta that may mediate the association between metal exposure and gestational age.