COOPERATIVE TISSUE BANK OF HIV POSITIVE MALIGNANCIES

描述(由申请人提供)： 艾滋病和癌症标本库(ACSB)，由NCI于1994年建立 癌症治疗和诊断科(OD-DCDT)，以促进对 艾滋病相关恶性肿瘤的发病机制和治疗，为人类免疫缺陷病毒- 相关恶性组织和临床结果数据已获批准 研究人员。俄亥俄州立大学ACSB联盟(OSU-ACSB)及其站点 在俄亥俄州、伊利诺伊州、田纳西州、佐治亚州和德克萨斯州，提议帮助 通过采购艾滋病毒感染组织和相关临床组织获得国家ACSB 来自美国中部地区17个州的结果，那里有40%的美国人 人口，32%的艾滋病毒/艾滋病感染者和25%的艾滋病/艾滋病毒病例 都被定位了。肯尼亚和乌干达这两个非洲国家的藏品有 提议增加获得与艾滋病毒相关的恶性肿瘤的机会。超过12,483 已经收集了样本，约占ACSB样本的23%。特定的 OSU-ACSB的目标是：1)获取新的艾滋病相关恶性组织， 来自临床病例的细胞和液体以及与 NCI资助的临床试验小组，如“艾滋病相关的口服化疗” 非洲的非霍奇金淋巴瘤“(1R01 CA83528-01)及建议储存的临床样本 非洲遗址，直到运输到OSU-ACSB；2)保存存档 石蜡包埋的艾滋病毒/艾滋病组织，强调提供组织显微 阵列(TMA)提交给经批准的调查人员。TMA保存HIV感染组织 从艾滋病毒流行开始和便利的研究精选 大量组织中的靶标。TMA受客户支持 OSU-ACSB利用进化技术开发的组织阵列数据系统(TADS) 美国国家病理信息学协会(API)的标准。TADS 向经批准的调查人员提供未经确认的患者临床数据，TMA 区块谱系，包括组织阵列H&E Digital的质量控制数据 图像，以及通过组织形态计量学和选定的测试进行质量评估。 研究人员组织阵列测试的分析将使用OSU-ACSB 先进的图像采集和分析设备/软件；3)工作 与NCI赞助的组织资源(如CHTN)一起优化NCI资金 为癌症研究人员和临床试验小组提供组织服务；4)至 与OD-DCTD、ACSB指导委员会、中央运营和 数据协调中心和所有ACSB财团增加保存的标本， 促进ACSB的使用，并与经批准的研究人员合作 为调查提供及时、优质的材料。

DESCRIPTION (provided by applicant): The AIDS and Cancer Specimen Bank (ACSB), established in 1994 by the NCI Division of Cancer Treatment and Diagnosis (OD-DCDT) to promote research into the pathogenesis and treatment of AIDS-related malignancies, provides HIV- associated malignant tissues and clinical outcome data to approved researchers. The Ohio State University ACSB Consortium (OSU-ACSB) with sites in Ohio, Illinois, Tennessee, Georgia and Texas proposes to assist the national ACSB by procurement of HIV infected tissues and associated clinical outcomes from a 17 state mid-region of the United States where 40% of the USA population, 32% of persons living with HIV/AIDS and25 % of all AIDS/HIV cases are located. Collections in two African countries, Kenya and Uganda, are proposed to increase access to HIV-associated malignancies. Over 12,483 samples or approximately 23% of ACSB samples have been collected. Specific OSU-ACSB aims are: 1) to procure fresh AIDS-associated malignant tissues, cells and fluids from clinical cases and donated samples from association with NCI funded clinical trial groups such as "Oral Chemotherapy in AIDS-related NHL in Africa" (1R01 CA83528-01) with clinical samples banked at proposed African sites until transported to the OSU-ACSB; 2) to preserve archived paraffin embedded HIV/AIDS tissues with emphasis on providing tissue micro arrays (TMAs) to approved investigators. TMAs preserve HIV infected tissues from the beginning of the HIV epidemic and facilitate the study of selected targets in large populations of tissues. The TMAs are supported by a custom tissue array data system (TADS) developed by the OSU-ACSB using evolving standards of the national Association for Pathology Informatics (API). TADS provides approved investigators with de-identified patient clinical data, TMA block pedigree, quality control data including tissue array H & E digital images, and quality assessment by tissue morphometrics and selected tests. Analysis of investigator tissue array tests will be available using OSU-ACSB sophisticated image acquisition and analysis equipment/software; 3) to work with NCI sponsored tissue resources such as the CHTN to optimize NCI funds for tissue service to cancer researchers and clinical trial groups; 4)to participate with the OD-DCTD, ACSB Steering Committee, Central Operations and Data Coordination Center, and all ACSB Consortia to increase banked specimens, to promote utilization of the ACSB and to work with approved researchers to provide timely and quality materials for investigations.