课题基金 / 基金详情

Recombinant Vaccines

Recombinant Vaccines
重组疫苗
批准号：
6808158
负责人：
BERNARD MOSS
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6808158
关键词：
AIDS therapy AIDS vaccines HIV infections Poxviridae disease biotechnology cellular immunity enzyme linked immunosorbent assay flow cytometry human immunodeficiency virus humoral immunity laboratory mouse nonhuman therapy evaluation nucleic acid sequence polymerase chain reaction recombinant virus simian immunodeficiency virus vaccine development vaccinia virus virus DNA virus antigen

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中文摘要
翻译
有许多疾病是没有疫苗的，而其他一些疾病的疫苗并不是最理想的或有显著的副作用。该项目的目标是确定病毒抗原的特征，确定体液和细胞免疫的目标，并利用这些信息开发候选疫苗。重组活疫苗和重组蛋白疫苗都在研发中。这些疫苗首先在小动物身上进行测试，然后在非人类灵长类动物身上进行测试。目前，我们正在研制针对HIV、Saars和天花的疫苗。
英文摘要
There are many diseases for which there are no vaccines and others for which the vaccines are not optimal or have significant side effects. The objectives of this project are to characterize viral antigens, determine targets of humoral and cell mediated immunity, and to use this information to develop candidate vaccines. Both live recombinant vaccines and recombinant protein vaccines are being developed. The vaccines are first tested in small animals and then in non-human primates. Presently we are working on vaccines for HIV, SAARS, and smallpox.
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会议论文
VIRUS HOST INTERACTIONS
REGULATION OF VACCINIA VIRUS GENE EXPRESSION
Development of Vaccinia Virus as an Expression Vector
Poxvirus Entry, Assembly, and Dissemination
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