Universal Edited MRS at 3T

项目摘要 Hadamard编码的编辑MRS允许同时在体内检测多种低浓度 神经代谢物在一个实验中。在该赠款的最后一个供资期间开发的方法正在 应用于六溴环十二烷研究，这是一项关于儿童发育的大型国家研究（约7，000名婴儿）。在这次更新中， 在此期间，我们将在整个生命周期队列中获得相同的采集协议，以揭示 在发育和衰老中的神经化学变化。在方法论上，我们将扩展编辑的效用， 通过解决长期存在的体素外（OOV）回波问题，将MRS应用于具有挑战性的大脑区域。 我们将优化采集，以减少OOV回波对每个具有挑战性的区域的影响，并开发 建模策略，以尽量减少其对代谢物定量的影响。我们还将开发智能 可以在序列被采集时实时检测OOV信号，并调整 采集响应，以减少OOV信号。最后，我们会继续进行宣传工作， 在以前赠款期间开发的方法，随着扫描器的更新而升级代码，并移植新的进展 回到旧的代码中，这样合作者就可以受益。

Project Summary Hadamard-encoded edited MRS allows simultaneous in vivo detection of multiple low-concentration neurometabolites in a single experiment. Methods developed in the last funded period of this grant are being applied in the HBCD study, a large national study of childhood development (~7,000 infants). In this renewal period, we will acquire the same acquisition protocol in a whole-lifespan cohort in order to reveal neurochemical changes in development and aging. Methodologically, we will then extend the utility of edited MRS into challenging areas of the brain by addressing the long-standing issue of out-of-voxel (OOV) echoes. We will optimize acquisitions to reduce the impact of OOV echoes for each challenging region and develop modeling strategies to minimize their impact on metabolite quantification. We will also develop intelligent acquisitions that can detect OOV signals in real-time as the sequence is being acquired and adjust the acquisition responsively to reduce OOV signals. Finally, we will continue the on-going work to disseminate methods developed during prior grant periods, upgrading code as scanners update and porting new advances back into older code so collaborators can benefit.