Mechanisms and Markers of Prostate Cancer Metastases

生物标本核心为项目1 - 5提供部分基础设施支持。这一核心将 提供一个组织良好和标准化的标本采集、储存、分发和相关系统 基于二十多年经验的临床/研究信息传播。一个关键 是我们的快速尸检计划在病理学方面将有一致性和质量保证， 组织样本分析。生物标本中心还参与维护一系列大型的 前列腺癌异种移植物系由核心研究者开发。这些异种移植物用于许多 PPG研究者进行研究，每项研究均由核心人员监督。 总体而言，本核心组的业务分为5个组成部分： 1.标本采集、处理、质量控制、储存和数据库登录; 2.一项开发计划，以不断提高我们获得组织的质量和效率 样品和衍生产品; 3.前列腺癌异种移植维持、开发和研究计划。 4.实验室服务，包括泌尿科医生对组织的解读和组织定位研究 病理学家、免疫组织化学、定量RT-PCR和免疫测定，即PSA和组织培养。 核心还将使用我们的异种移植资源进行临床前研究; 5.一项行政计划，从少数民族患者中获取样本，优先分配 标本，进行质量控制计划，并确保患者保密性和符合IRB 要求.此外，核心小组还为项目调查人员提供生物统计支持， 核心相关任务。 本计划项目中详细介绍的每个研究项目的性能要求， 研究人员可随时取得有充分记录的临床样本和有关的生物模型。的 指导生物样本核心的研究人员也制定了一项政策， 在全球范围内向非PPG研究者提供样本资源。总的来说，生物标本核心是一个 这个项目的关键组成部分。

The Biospecimen Core provides part of the infrastructure support for Projects 1 - 5. This Core will provide a well-organized and standardized system of specimen collection, storage, distribution and related clinical/research information dissemination that is based on over two decades of experience. A critical aspect is our Rapid Autopsy Program. There will be consistency and quality assurance in the pathological analysis of tissue specimens. The Biospecimen Core is also involved in the maintenance of a large series of prostate cancer xenograft lines developed by Core investigators. These xenografts are used for a number of studies by the PPG investigators and each study is overseen by Core personnel. Overall, the operations of this Core group into 5 components: 1. Specimen acquisition, processing, quality control, storage and accessioning into databases; 2. A development program to continually improve the quality and efficiency with which we obtain tissue samples and derivative products; 3. A prostate cancer xenograft maintenance, development and study program. 4. Laboratory services, including interpretation of tissues and tissue localization studies by a urologic pathologist, immunohistochemistry, quantitative RT-PCR, and immunoassays, i.e. PSA, and tissue culture. The Core will also perform pre-clinical studies using our xenograft resources; 5. An administrative program to obtain samples from minority patients, prioritize the distribution of specimens, conduct a quality control program, and to ensure patient confidentiality and compliance with IRB requirements. Furthermore, the Core provides biostatistical support to the project investigators as well as for Core related tasks. The performance of each of the research projects detailed in this program project mandates that investigators have ready access to well documented clinical specimens and relevant biological models. The investigators directing the Biospecimen Core also make it a policy to provide excess prostate cancer specimen resources to non-PPG investigators on a world-wide basis. Overall, the Biospecimen Core is a critical component of this program project.