EXERCISE INTOLERANCE INDUCED BY HYPERTHYROIDISM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的主要目的是深入了解甲亢患者对运动和其他身体应激反应改变的机制。将研究交感神经系统、骨骼肌血流和代谢的调节以及物理应激（热皮肤试验、下体负压、冷压试验和渐进式握力运动）期间的体温调节功能，作为对物理应激反应改变做出贡献的可能机制。健康受试者将接受安慰剂和口服三碘甲状腺原氨酸（T3）给药以诱导甲状腺功能亢进。将检查受试者以确定甲状腺功能亢进症是否改变了交感神经系统、肌肉血流和代谢以及体温调节功能的反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The key objectives of the present study are to gain insight into the mechanisms producing altered responses to exercise and other physical stress in hyperthyroid subjects. Regulation of the sympathetic nervous system, skeletal muscle blood flow and metabolism, and thermoregulatory function during physical stress (thermo skin test, lower body negative pressure, cold pressure test, and progressive handgrip exercise) will be studied as possible mechanisms contributing to the altered response to physical stress. Healthy subjects will receive placebo and oral triiodothyronine (T3) administration to induce hyperthyroidism. Subjects will be examined to determine if responses of sympathetic nervous system, muscle blood flow and metabolism, and thermoregulatory functions are altered by hyperthyroidism.