CEREBRAL AUTOREGULATION OF HEALTHY AND DISEASED BRAIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在今天的美国，缺血性中风是导致残疾和死亡的主要原因，每年影响大约70万人，预计每十年的成本超过4000亿美元。治疗的主要挑战之一是相对无法获得脑组织的生理监测。CT、MRI和PET扫描等成像手段需要大型且昂贵的仪器，严重限制了它们在患者住院期间的使用。因此，旨在增加卒中区域及其周围血流量的卒中干预措施，通常是根据经验或临床恶化而开出的。通过提供在床边连续测量CBF的技术，漫反射光学技术具有显著改变患者护理的潜力，从而允许根据组织反应为每个患者优化和个性化管理干预措施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ischemic stroke is the leading cause of disability and a leading cause of mortality in the US today, affecting approximately 700,000 people annually with a projected cost of over $400 Billion per decade. One of the major treatment challenges is the relative inaccessibility of brain tissue to physiological monitoring. Imaging modalities such as CT, MRI, and PET scanning require large and costly instrumentation that severely limit their use during patient hospitalization. Thus stroke interventions, intended to increase blood flow in and around the stroke region, are usually prescribed empirically or in response to clinical deterioration. Diffuse optics holds potential to dramatically change patient care by providing technology to measure CBF continuously at the bedside, thereby permitting management interventions to be optimized and individualized for each patient based on tissue response.