CORE GRANT FOR VISION RESEARCH

描述（申请人提供）：在过去的四年里，田纳西大学（UT）孟菲斯视觉研究核心补助金提供了支持，这对实现我们的主要计划目标至关重要：1）建立新的汉密尔顿眼科研究所，提供15,000平方英尺的新研究实验室和核心设施，再加上计划增加15个，第三阶段的建筑面积为2000平方英尺; 2）招聘7名杰出的博士或医学博士。视觉研究系博士; 3）与圣裘德儿童研究医院和一些UT研究中心建立强有力的研究和培训合作。个人核心参与者的成就同样令人印象深刻。自从我们上次提交核心补助金以来，22名利用核心设施的参与者已经出版了335份出版物。下一个供资期的计划包括加强现有的两个核心单元。成像模块包括三个用于光学显微镜的高分辨率数字图像分析系统，一个快速响应的钙成像系统和显微镜程序的技术援助。要求提供资金用于新的共焦显微镜和低温恒温器。分子生物学模块提供自动DNA测序和基因分型、定量实时PCR和基因阵列芯片扫描技术。将用核心补助金为这一单元购买的主要新设备包括台风工作站成像仪、紫外96孔板阅读器和超浓缩仪。额外的视觉研究教师将被招募，以填补新创建的空间在汉密尔顿眼科研究所。圣裘德儿童研究医院和UT之间的合作将随着两个机构的研究人员获得大型跨学科赠款的预期奖励而增长。这两个机构的管理部门都大力支持视觉研究的持续发展。

DESCRIPTION (provided by applicant): For the past four years, the University of Tennessee (UT) Memphis Core Grant for Vision Research has provided support that has been critical for accomplishing our major programmatic goals of 1) building of the new Hamilton Eye Institute to provide 15,000 square feet of new research laboratories and core facilities, plus plans for an additional 15,000 square feet in Phase III of the construction; 2) recruitment of seven exceptional Ph.D or M.D./Ph.D vision research faculty; 3) building strong research and training collaborations with St. Jude Children's Research Hospital and with a number of UT research centers. The accomplishments of individual Core participants have equally impressive. Since our last Core Grant submission, the 22 participants utilizing Core facilities have produced over 335 publications. Plans for the next funding period include strengthening the two existing Core Modules. The Imaging Module consists of three high-resolution digital image analysis systems for light microscopy, a rapid-response calcium imaging system and technical assistance for microscopy procedures. Funds for a new confocal microscope and cryostat are requested. The Molecular Biology Module provides automated DNA sequencing and genotyping, quantitative real-time PCR, and gene array chip scanning technology. Major pieces of new equipment to be purchased with Core Grant funds for this module include a Typhoon Workstation Imager, UV 96 well plate reader, and ultracentrifuge. Additional vision research faculty will be recruited to fill the newly created space in the Hamilton Eye Institute. Collaborations between St. Jude Children's Research Hospital and UT will grow with the expected award of large interdisciplinary grants involving investigators from both institutions. The administration of both institutions strongly supports the continued growth of vision research.