Core Center for Vision Research

描述：继续寻求密歇根大学视觉研究核心中心的支持。 需要对五个单元提供支助：（1）一个仪器车间单元，负责设计和建造机械仪器，配备一名仪器制造商;（2）一个电子和计算机单元，负责设计和建造电子设备并协助研究计算机，配备一名电子工程师; 3）用于处理眼组织以进行光学和电子显微镜检查、免疫组织化学和原位杂交的形态学和成像模块，以及研究照片和数字图像的制作，由一名技术人员担任工作人员; 4）一个饲养和护理用于视觉研究的实验动物的饲养舱，由一名兽医技术人员担任工作人员;和5）微阵列和分子生物学模块，用于为研究者提供分子生物学所需的仪器和服务，处理和扫描商业基因芯片和定制微阵列载玻片，用于研究眼组织中的基因表达，由技术人员担任工作人员。密歇根大学视觉研究核心中心的具体目标是改善视觉科学家的研究环境，促进视觉系统及其疾病的合作研究，并扩大该校园的视觉研究，使非视觉科学家的技能和观点能够影响视觉系统的研究问题。18名参与研究者目前持有19项NEI赠款。这些研究人员的研究兴趣是多样化的，包括电生理学，神经生物学，生物化学，分子生物学，分子遗传学，发育生物学，生物统计学，免疫学和临床眼科学。核心中心位于W.K.凯洛格眼科中心，一个120,000平方米。英尺建筑包含专用于每个模块的空间，加上基础和临床研究的最先进设施。

DESCRIPTION: Continued support is sought for the Core Center for Vision Research at the University of Michigan. Support for five modules is requested: 1) an Instrument Shop Module for designing and constructing mechanical instrumentation, staffed by an instrument maker; 2) an Electronics and Computer Module for designing and constructing electronics equipment and assistance with research computers, staffed by an electronics engineer; 3) a Morphology and Imaging Module for the processing of ocular tissue for light and electron microscopy, immunohistochemistry and in situ hybridization, as well as the production of research photographs and digital images, staffed by a technician; 4) a Vivarium Module for the housing and care of laboratory animals used in vision research, staffed by a veterinary technician; and 5) a Microarray and Molecular Biology Module for providing investigators access to instrumentation and services necessary for molecular biology and the processing and scanning of commercial gene chips and custom microarray slides for the investigation of gene expression in ocular tissues, staffed by a technician. The specific aims of the Core Center for Vision Research at the University of Michigan are to enhance the research environment for vision scientists, facilitate collaborative studies of the visual system and its diseases, and expand vision research on this campus to bring the skills and perspectives of non-vision scientists to bear upon research issues of the visual system. The 18 participating investigators currently hold 19 NEI grants. The research interests of these investigators are diverse and include electrophysiology, neurobiology, biochemistry, molecular biology, molecular genetics, developmental biology, biostatistics, immunology, and clinical ophthalmology. The Core Center is housed within the W.K. Kellogg Eye Center, a 120,000 sq. ft. building containing space dedicated to each of the modules, plus state-of-the-art facilities for basic and clinical research.