Modulating heat shock protein expression in skeletal muscle to improve the pathophysiology of muscular dystrophy

杜氏肌营养不良症（DMD）是最常见和最严重的肌肉营养不良症。营养不良的肌肉很脆弱，容易受伤，损伤后再生能力差。钙处理缺陷与这些过程有关。我们发现，上调应激蛋白——热休克蛋白（HSPs）的水平可以改善肌肉萎缩症患者的钙调节。调节HSP反应具有显著的延迟发病或减缓DMD进展的潜力。

Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy. Dystrophic muscles are fragile, prone to injury, and regenerate poorly after damage. Defective calcium handling has been implicated in these processes. We have revealed that upregulating levels of stress proteins called _heat shock proteins� (HSPs) can improve calcium regulation in muscular dystrophy. Modulating the HSP response has significant potential to delay the onset or slow the progression of DMD.