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Modulating Inflammatory and Fibrogenic Pathways in Kidney Disease using a novel antagonist of Protease-Activated-Receptor-2

Modulating Inflammatory and Fibrogenic Pathways in Kidney Disease using a novel antagonist of Protease-Activated-Receptor-2
使用蛋白酶激活受体 2 的新型拮抗剂调节肾脏疾病的炎症和纤维化途径
批准号:
nhmrc : 1083131
负责人:
A/Pr David Nikolic-Paterson
金额:
$39.89万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31

项目摘要

项目成果

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相关文献

中文摘要
翻译
慢性肾脏疾病(CKD)现在影响了工业化国家10%的成年人。目前的治疗大多无效。因此,开发更好的慢性肾病治疗方法将对公共卫生产生重大影响。由昆士兰大学的研究小组成员开发的一种新的实验性抗炎药将用于预防或减轻CKD的进展,将使用三种建立良好且临床相关的肾脏疾病动物模型来测试这种药物的能力。
英文摘要
Chronic kidney disease (CKD) now affects 10% of adults in industrialised countries. Current treatments are largely ineffective. Thus developing better CKD treatments will have substantial public health benefit. Three well established and clinically relevant animal models of kidney disease will be used to test the ability of a new experimental anti-inflammatory drug, developed by members of this research team at The University of Queensland, to prevent or lessen the progression of CKD.
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会议论文
TGF-beta/Smad signalling in macrophage-mediated renal fibrosis.
  • 批准号:
    nhmrc : 1122073
  • 项目类别:
    Project Grants
  • 资助金额:
    $46.66万
  • 财政年份:
    2017
  • 负责人:
    A/Pr David Nikolic-Paterson
  • 依托单位:
Defining the central role of podocyte depletion in the development, progression and management of glomerular disease
  • 批准号:
    nhmrc : GNT1121793
  • 项目类别:
    Project Grants
  • 资助金额:
    $69.09万
  • 财政年份:
    2017
  • 负责人:
    A/Pr David Nikolic-Paterson
  • 依托单位:
Defining the central role of podocyte depletion in the development, progression and management of glomerular disease
  • 批准号:
    nhmrc : 1121793
  • 项目类别:
    Project Grants
  • 资助金额:
    $47.17万
  • 财政年份:
    2017
  • 负责人:
    A/Pr David Nikolic-Paterson
  • 依托单位:
TGF-beta/Smad signalling in macrophage-mediated renal fibrosis.
  • 批准号:
    nhmrc : GNT1122073
  • 项目类别:
    Project Grants
  • 资助金额:
    $68.37万
  • 财政年份:
    2017
  • 负责人:
    A/Pr David Nikolic-Paterson
  • 依托单位:
海外基金