DOPAMINE-RLS CONNECTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 不宁腿综合症(RLS)是一种感觉-运动障碍，多巴胺能系统和脑铁似乎在其中发挥作用。超过98%的受试者对L-多巴的显著症状反应，以及多巴胺(DA)拮抗剂诱导的类RLS症状，为多巴胺能系统在RLS症状本身的产生中所起的作用提供了令人信服的证据。尸检、脑脊液、核磁共振和静脉铁治疗数据表明脑铁缺乏在RLS中的作用。 这项研究旨在探索白天漏斗结节(催乳素脉动性)、黑质纹状体(中脑和纹状体的PET成像)和中脑边缘(腹侧纹状体/伏隔核的PET成像)多巴胺能系统的异常。上午8：30-12：00将使用最先进的PET成像技术测量DA-2受体(D2R)结合电位和Bmax、DAT在DA系统中发现的任何变化都将与MRI测量的局部脑铁浓度和临床严重程度的测量相关联。特发性RLS患者和年龄匹配的对照组将在此阶段进行研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Restless Legs Syndrome (RLS) is a sensory-motor disorder in which the dopaminergic system and brain iron appear to play a role. The dramatic symptomatic response to L-DOPA in over 98% of RLS subjects and the induction of RLS-like symptoms with dopamine (DA) antagonists provide convincing evidence for the role of the dopaminergic system in the production of RLS symptoms per se. The autopsy, CSF, MRI, and IV iron treatment data indicate a role of BRAIN iron deficiency in RLS. This study is designed to explore for abnormalities in the tuberoinfundibular (prolactin pulsatility), nigrostriatal (PET imaging of midbrain and striatum), and mesolimbic (PET imaging of ventral striatum/n. accumbens) Dopaminergic systems during the day. The DA-2 receptor (D2R) binding potential and Bmax, DAT will be measured with state-of-the-art PET imaging techniques from 8:30 - 12:00 AM. Any changes that are found in the DA system will be correlated with MRI measures of regional brain iron concentrations and measures of clinical severity. Idiopathic RLS patients and aged-matched controls will be studied in this Phase.