Core Center for Vision Research

描述：为密歇根大学视觉研究核心中心寻求持续支持。需要支持五个模块：1)一个仪表车间模块，用于设计和制造机械仪表，由仪表制造商配备；2)电子和计算机模块，用于设计和构建电子设备，并协助研究计算机，由电子工程师配备；3) a形态学和成像模块，用于光学和电子显微镜、免疫组织化学和原位杂交处理眼组织，以及生产研究照片和数字图像，配备一名技术人员；4)一个Vivarium模块，用于饲养和照顾用于视觉研究的实验动物，配备一名兽医技术人员；5)微阵列和分子生物学模块，为研究人员提供分子生物学所需的仪器和服务，以及商业基因芯片和定制微阵列载玻片的处理和扫描，用于研究眼部组织中的基因表达，由技术人员配备。密歇根大学视觉研究核心中心的具体目标是增强视觉科学家的研究环境，促进视觉系统及其疾病的合作研究，并扩大校园内的视觉研究，将非视觉科学家的技能和观点带到视觉系统的研究问题上。18名参与研究人员目前持有19项NEI资助。这些研究者的研究兴趣是多样化的，包括电生理学、神经生物学、生物化学、分子生物学、分子遗传学、发育生物学、生物统计学、免疫学和临床眼科学。核心中心位于凯洛格眼科中心，占地12万平方英尺。每个模块都有专门的空间，加上最先进的基础和临床研究设施。

DESCRIPTION: Continued support is sought for the Core Center for Vision Research at the University of Michigan. Support for five modules is requested: 1) an Instrument Shop Module for designing and constructing mechanical instrumentation, staffed by an instrument maker; 2) an Electronics and Computer Module for designing and constructing electronics equipment and assistance with research computers, staffed by an electronics engineer; 3) a Morphology and Imaging Module for the processing of ocular tissue for light and electron microscopy, immunohistochemistry and in situ hybridization, as well as the production of research photographs and digital images, staffed by a technician; 4) a Vivarium Module for the housing and care of laboratory animals used in vision research, staffed by a veterinary technician; and 5) a Microarray and Molecular Biology Module for providing investigators access to instrumentation and services necessary for molecular biology and the processing and scanning of commercial gene chips and custom microarray slides for the investigation of gene expression in ocular tissues, staffed by a technician. The specific aims of the Core Center for Vision Research at the University of Michigan are to enhance the research environment for vision scientists, facilitate collaborative studies of the visual system and its diseases, and expand vision research on this campus to bring the skills and perspectives of non-vision scientists to bear upon research issues of the visual system. The 18 participating investigators currently hold 19 NEI grants. The research interests of these investigators are diverse and include electrophysiology, neurobiology, biochemistry, molecular biology, molecular genetics, developmental biology, biostatistics, immunology, and clinical ophthalmology. The Core Center is housed within the W.K. Kellogg Eye Center, a 120,000 sq. ft. building containing space dedicated to each of the modules, plus state-of-the-art facilities for basic and clinical research.