Developmental Funds

在过去的资助期内，希望之城综合癌症中心为12个试点项目颁发了奖项 485,000美元的项目，以鼓励中心的合作项目或高风险研究 会员。超过2800 000美元的赠款来自其中几个合作项目，包括一个项目 授予我们新的淋巴瘤孢子和几个R01。该中心还在两年内提供了100,000美元 支持正在发展的核心--临床免疫生物学相关研究实验室，这是一个新的 此续订应用程序中的共享资源。在下一个供资期间，合作伙伴关系委员会已承诺 一个雄心勃勃的目标：通过招聘和计划加快其翻译研究活动，并 基础设施发展，以便我们以快速、安全和有效的方式提高 创新的实验室发现达到内部临床试验。我们建议使用我们的开发工具 要求每年共计250,000美元的资金，以支持如下方案增长： ？每年100,000美元，用于三个临床项目中的2至3个项目：乳房、前列腺和 胸部恶性肿瘤？我们已将其作为进化为中心研究计划的目标 下一次CCSG续签的时机。 ？每个项目配对一名疾病领域的临床和实验室研究人员 我们将通过开发三种新的共享资源来推进我们的基础设施： 高通量筛选以确定肿瘤治疗靶点的小分子调节剂 由中心调查人员确定(3年内每年5万美元) ？追求小分子结构/活性关系的合成和生物大分子化学 (3年50,000元/年) ？调查研究，以协助我们的人口科学研究人员从分散的地方收集数据 在符合机构和政府规定的有效过程中研究主题 条例(为期3年，每年5万元)

In the past funding period, the City of Hope Comprehensive Cancer Center distributed awards for 12 pilot projects in the amount of $485,000 to encourage collaborative projects or high-risk research of Center members. Grants exceeding $2,800,000 resulted from several of these collaborations, including one project grant of our new lymphoma SPORE and several R01s. The Center also provided $100,000 over 2 years in support of the developing core, Clinical Immunobiology Correlative Studies Laboratory, which is a new shared resource in this renewal application. During the next funding period, the COHCCC has undertaken an ambitious goal: to accelerate its translational research activities through recruitment and program and infrastructure development so that we increase¿with speed, safety, and effectiveness¿the density of innovative laboratory discoveries reaching in-house clinical trials. We propose to use our developmental funds, a requested total of $250,000 yearly, to support programmatic growth as follows: ¿ $100,000 yearly for 2 to 3 projects focused in the three clinical programs¿breast, prostate, and thoracic malignancies¿that we have targeted for evolution into Center research programs on the occasion of the next CCSG renewal. ¿ Each project to pair a clinical and laboratory researcher in the disease area We will advance our infrastructure by developing three new shared resources: ¿ High Throughput Screening to identify small molecular modulators of cancer therapeutics targets identified by Center investigators ($50,000/year for 3 years) ¿ Synthetic and Biopolvmer Chemistry to pursue small-molecule structure/activity relationships ($50,000/year for 3 years) ¿ Survey Research to assist our population sciences investigators in gathering data from dispersed research subjects in an efficient process that is compliant with institutional and governmental regulations ($50,000/year for 3 years)