DEVELOPMENT OF MEDIAL TEMPORAL LOBE FUNCTIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目研究(A)猴子海马体和周围中枢功能的发育，(B)早期损害这些脑区对记忆过程和社会纽带成熟的长期后果，以及(C)与成人损害相比，这些早期损害导致的其他大脑系统的解剖重组。在本年度，我们继续对正在进入青春期和成年早期的猴子进行行为训练，这些猴子已经准备好了新生损伤的海马体和它们的假手术对照组。我们评估了他们在长时间延迟中识别物体和地点的能力，在执行任务时在线持有信息的能力，以及他们的社交技能和情绪反应。我们还增加了6只有新生儿裂孔周围皮质损伤的幼猴，以及2名假手术和2名正常婴儿作为对照。这些动物已经在生命的前6个月接受了物体识别、记忆、社会互动和情感反应的测试。随着这些动物的成熟，我们将继续对它们进行行为测试。我们的主要动机是希望通过这样的研究，能够建立大脑对损伤做出反应的原则，最终将发现减轻甚至消除这种影响的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project investigates (a) the development of hippocampal and perirhinal corex functions in monkeys, (b) the long-term consequences of early insult to these brain areas on the maturation of memory processes and social bonds, and (c) the anatomical reorganization of other brain systems resulting from these early lesions as compared to adult lesions. In the current year, we continued to behaviorally trained monkeys that we have prepared with neonatal lesions of the hippocampus and their sham-operated controls as they are reaching adolescence and early adulthood. We assessed their abilities to recognize objects and places over long delays, to hold information on line while performing a task, as well as their social skills and emotional reactivity. We also added 6 infant monkeys with neonatal lesions of the perirhinal cortex as well as 2 sham-operated and 2 normal infants that will serve as controls. These animals have already been tested on object recognition memory, social interactions and emotional reactivity during the first 6 months of life. We will continue to pursue the behavioral testing of these animals as they will mature. Our primary motivation is the hope that, through such research, principles of the brain's response to damage can be established that will lead ultimately to the discovery of ways in which such effects can be alleviated or even eliminated.