AMYGDALA-ORBITAL FRONTAL INTERACTION AND REWARD EXPECTANCY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在灵长类动物中，眼眶额叶皮质(ORB)或杏仁核(AMYG)的损伤导致使用积极或消极结果来指导行为反应的缺陷。然而，它们在灵活的目标导向行动中各自扮演的角色仍然不确定。我们正在努力改进和实施可逆失活的使用，通过冷却，达到灵长类认知功能的精确神经底物。在这个项目中，这项技术将使我们能够区分ORB和AMYG在猴子解释视觉刺激的强化价值并根据学习的偏好和当前的动机状态自适应地改变选择反应的能力中所扮演的角色。已经分配了两只猴子，并开始了行为训练。用于暂时冷却大脑区域的微型探测器正在建造中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Orbital frontal cortex (ORB) or amygdala (AMYG) damage in primates yields deficits in using positive or negative outcomes to guide behavioral responses. Yet, their respective role in flexible goal-directed actions remains uncertain. We are working to refine and implement the use of reversible inactivation, via cooling, to the precise neural substrate of cognitive functions in primates. For this project, the technique will allows us to distinguish the role of ORB and AMYG in monkeys' ability to interpret the reinforcing value of visual stimuli and alter adaptively their choice responses upon both learned preferences and current motivational state. Two monkeys have been assigned and have begun the behavioral training. Microprobes for temporarily cooling brain areas are being constructed.